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1
Content available Surface modifications of biomaterial with different cold plasma reactors to improve cell adhesion
Terebun Piotr, Wójcik Michał, Trzaskowska Marta, Kwiatkowski Michał, Zarzeczny Dawid, Kazimierczak Paulina, Pawłat Joanna, Przekora Agata
Engineering of Biomaterials
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2022
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vol. 25, no. 165
2--6
EN
There is a growing trend in the engineering of biomaterials, focusing on surface modifications of biomaterials to improve their mechanical strength, corrosion resistance, and biological properties. Cold plasma treatment may improve biological properties of biomaterials for biomedical applications by enhancing their integration with host tissue. This study investigated the influence of different cold plasma treatments on the surface properties of a polysaccharides- -based biomaterial to improve cell adhesion to its surface. The samples were subjected to plasma treatment using three different reactors operating at atmospheric pressure: gliding arc discharge (GAD) reactor, dielectric barrier discharge (DBD) plasma jet, and DBD surface reactor. Next, surface chemistry of the biomaterial after plasma treatment was determined by ATR-FTIR analysis. Furthermore, a cell adhesion assay on the samples was carried out using normal human skin fibroblasts (BJ cell line). The attenuated total reflection Fourier transform infrared analysis (ATR- -FTIR) showed that new potential functional groups could be formed on the material surface after plasma treatment. However, plasma treatment of the samples did not enhance cell adhesion to the surface of the polysaccharides-based biomaterial. Thus, the obtained results indicate that plasma treatment using GAD reactor, DBD plasma jet, and DBD surface reactor was not effective for surface modification and cell responses.
2
Content available Microstructure and surface free energy of light-cured dental composites after their modification with liquid rubber
Sowa Monika, Przekora Agata, Pałka Krzysztof
Engineering of Biomaterials
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2022
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vol. 25, no. 164
9--15
EN
The use of liquid rubber as a component of light-cured dental composites is one of the methods of increasing their fracture toughness. It also reduces polymerization shrinkage and offers the potential to lower water sorption. The aim of the study was to evaluate the miscibility of liquid rubber in composite matrix resins as well as changes in the wettability and surface free energy (SFE) values of commercial lightcuring composites after their modification with liquid rubber. The research materials were Flow Art and Boston (Arkona) light-cured composites and resin mixtures used in their production. Liquid rubber Hypro 2000X168LC VTB (Huntsman Int.) was used as a modifier. The solubility of liquid rubber was assessed under light microscopy. The contact angle and SFE measurements were made on a DSA30 goniometer (Kruss) using water and diiodomethane. It was found that the liquid rubber solubility depended mainly on the viscosity of the resin, which was related to the amount of BisGMA. The resulting mixture showed good temporal stability without larger domains. The curing process released the liquid rubber as a separate phase formed as spherical domains. The morphology of these domains was homogeneous and their size did not exceed 50 µm in diameter. The presence of liquid rubber in modified composites increased their hydrophobicity and reduced the surface free energy value. The obtained properties might help to reduce the formation of bacterial biofilm on dental fillings.
3
Content available The use of a hydrocolide dressing on a chronic wound - case study
Wilczyńska Anna, Wójcik Michał, Przekora Agata, Ziętek Jerzy, Adaszek Łukasz
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
58
4
Content available The effect of nano-HA-based biomaterial on macrophage polarization and osteogenic differentiation in co-culture system in vitro
Kazimierczak Paulina, Przekora Agata
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
14
5
Content available Superabsorbent vitamin C-enriched chitosan-agarose biomaterial for exuding wound management
Vivcharenko Vladyslav, Wojcik Michał, Palka Krzysztof, Przekora Agata
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
50
6
Content available Poly(L-DOPA)-modification of curdlan hydrogel for safe and effective drug binding and release
Michalicha Anna, Roguska Agata, Przekora Agata, Budzyńska Barbara, Belcarz Anna
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
46
7
Content available Human spongy bone explant – a useful ex vivo model for implant osseointegration testing
Przekora Agata, Kazimierczak Paulina, Wójcik Michał
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
12
8
Content available Bioactive hydrocolloid-type biomaterials for potential management of highly exuding wounds
Wojcik Michał, Kazimierczak Paulina, Vivcharenko Vladyslav, Przekora Agata
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
49
9
Content available Bioactive curdlan/agarose dressing enriched with gentamicin for infected wounds – pilot studies
Wójcik Michał, Wilczyńska Anna, Vivcharenko Vladyslav, Kazimierczak Paulina, Adaszek Łukasz, Przekora Agata
Engineering of Biomaterials
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2021
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Vol. 24, no. 160
2--7
EN
The problem of treating chronic wounds is widespread throughout the world and carries a huge cost. Biomaterials engineering tries to solve this problem by creating innovative bioactive dressings dedicated to specific types of wounds. Both synthetic and natural polymers are the main base to produce wound dressings. Biopolymers have the advantage over synthetic polymers by being more biocompatible, non-toxic, biodegradable, and eco-friendly. The aim of this work was to produce a bioactive biomaterial based on natural polymers with potential applications to manage chronic highly exuding and infected wounds. A newly developed method for chemical synthesis of the curdlan/agarose biomaterial at high temperature combined with freeze-drying process resulted in a superabsorbent dressing material with antibiotic immobilized. The obtained biomaterial was subjected to basic microbiological in vitro tests and a cytotoxicity assay according to ISO 10993-5. Moreover, the experimental treatment of the infected wound in a veterinary patient was performed using the developed material. Based on the conducted research, it was proved that the produced dressing is not toxic to normal human skin fibroblasts. An additional advantage of the biomaterial is its ability to inhibit the growth of harmful microorganisms, such as Staphylococcus aureus and Pseudomonas aeruginosa. Furthermore, the experimental treatment confirmed the validity of using the produced biomaterial as a dressing dedicated to the treatment of difficult-to-heal infected wounds. To summarize, the produced biomaterial possesses great potential to be used as a wound dressing for infected wounds.
10
Content available Osteoblasts response to novel chitosan/agarose/hydroxyapatite bone scaffold – studies on MC3T3-E1 and hFOB 1.19 cellular models
Kazimierczak Paulina, Vivcharenko Vladyslav, Truszkiewicz Wiesław, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 151
24--29
EN
Since it is known that various cell lines may ex-press different behaviours on the scaffolds surface, a comprehensive analysis using various cellular mo-dels is needed to evaluate the biomedical potential of developed biomaterials under in vitro conditions. Thus, the aim of this work was to fabricate bone scaffolds composed of a chitosan-agarose matrix reinforced with nanohydroxyapatite and compare the biological response of two cell lines, i.e. mouse calvarial preosteoblasts (MC3T3-E1 Subclone 4) and human foetal osteoblasts (hFOB 1.19). Within this study, the osteoblasts number on the scaffold surface and the osteogenic markers level produced by MC3T3-E1 and hFOB 1.19 cells were determined. Furthermore, changes in calcium and phosphorous ions concentrations in the culture media dedicated for MC3T3-E1 and hFOB 1.19 were estimated after the biomaterial incubation. The obtained results proved that the fabricated biomaterial is characterized by biocompatibility and osteoconductivity since it favours osteoblasts attachment and growth. It also supports the production of osteogenic markers (collagen, bALP, osteocalcin) by MC3T3-E1 and hFOB 1.19 cells. Interestingly, the developed biomaterial exhibits different ion reactivity values in the two culture media dedicated for the mentioned cell lines. It was also revealed that mouse and human osteoblasts differ in the cellular response to the fabricated scaffold. Thus, the use of at least two various cellular models is recommended to carry out a reliable biological characterization of the novel biomaterial. These results demonstrate that the tested bone scaffold is a promising biomaterial for bone regeneration applications, however further biological and physicochemical experiments are essential to fully assess its biomedical potential.
11
Content available Novel highly biocompatible chitosan/agarose film for potential application as skin substitute
Vivcharenko Vladyslav, Kazimierczak Paulina, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 153 spec. iss.
20
12
Content available Novel agarose/β-1,3-glucan foam as promising biomaterial for skin regeneration applications
Wójcik Michał, Kazimierczak Paulina, Vivcharenko Vladyslav, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 153 spec. iss.
21
13
Content available Modification of hydroxyapatite by anionic substitution
Borkowski Leszek, Przekora Agata, Belcarz Anna, Józefaciuk Grzegorz, Ginalska Grażyna
Engineering of Biomaterials
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2019
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Vol. 22, no. 153 spec. iss.
29
14
Content available In vitro evaluation of cellular response to novel agarose/chitosan/HA scaffold
Kazimierczak Paulina, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 153 spec. iss.
18
15
Content available Highly macroporous chitosan/agarose/HA bone scaffold produced by combination of freeze- drying with gas-foaming agent
Kazimierczak Paulina, Pałka Krzysztof, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 153 spec. iss.
17
16
Content available Development of a new production method of foam-like wound dressings for skin regeneration
Vivcharenko Vladyslav, Kazimierczak Paulina, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
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2019
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Vol. 22, no. 152
16--20
EN
Chitosan is widely used to prepare films, hydro-gels, cryogels, sponges, fibers and other various biomaterials used in the tissue engineering field. It is one of the best processable polysaccharides used in biomedicine. However, its stability is generally lower as compared with others, due to its pH sensitivity and hydrophilic character. Using chitosan in combination with agarose may not only improve chemical and mechanical properties of the resultant material (by the formation of a biocomposite), but also lead to the formation of a gel imitating physical attributes of the extracellular matrix. Moreover, the combination of these two polysaccharides has a promising ability to improve the stability of chitosan and to increase fibroblasts’ affinity to agarose. Characteristic advan-tageous features of these natural polymers raise a wide interest in tissue engineering. The aim of this study was to develop and optimize a new method to produce a highly biocompatible foam-like chitosan/agarose wound dressing for skin healing applications. The production process optimization helped to obtain the absorbent foam-like biomaterial which is non-toxic to skin fibroblasts and does not conduce their adhesion. Employing sodium bicarbonate as the main agent in the foaming reaction not only led to obtaining the foam-like structure but also neutralized the acidic pH, making the material non-toxic and non-irritating to the skin. In conclusion, the new foam-like biomaterial has great potential for biomedical applications as the wound dressing accelerating the healing process of the damaged tissues.
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