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A simple HPLC method for the determination of butorphanol tartrate and ondansetron hydrochloride in patient-controlled analgesia solution

Fang B., Wang L., Chen F., Li P., Shi X.

Acta Chromatographica

2018

Vol. 30, no. 1

43--46

A simple and rapid high-performance liquid chromatographic (HPLC) method was established for simultaneous determination of butorphanol tartrate and ondansetron hydrochloride in analgesic mixture samples used for patient-controlled analgesia (PCA). The separation of butorphanol tartrate and ondansetron hydrochloride in PCA solution was carried out on phenomenex C18 column (4.6 mm × 150 mm, 5 μm) using 50 mM sodium acetate (pH 4.0) buffer and acetonitrile (72:28, v/v). Flow rate was 1.0 mL min−1 with a column temperature of 30 °C, and detection wavelength was carried out at 280 nm and 306 nm. Validation of the method was made in terms of specificity, linearity, accuracy, and intra- and inter-day precision, as well as quantification and detection limits. The developed method was successfully used to evaluate the chemical stability of butorphanol tartrate and ondansetron hydrochloride in analgesic mixtures at the usual concentration used for PCA.

Preparation and application of gold electrode modified with Ag nanoparticles and L-cysteine

Fang B., Wang G.-F., Li M.-G., Gao Y.-C., Kan X.-W.

Chemia Analityczna

2005

Vol. 50, No. 2

419-428

Gold electrode modified with silver nanoparticles and L-cysteine (Ag/L-Cys/Au CME) has been prepared. Its electrochemical behaviour was compared to that of bare gold electrode using cyclic voltammetry (CV). It has been found that at the modified electrode the redox process of hydroquinone proceeds faster. The linear dependence between the oxidation peak height of hydroquinone and its concentration was observed in the range from 3.0 x 10-6 to 2.0 x 10-3 mol L-1. The corresponding regression equation was: i p(μA) = -0.05612+ 1.13763c(μmol L-1); r = 0.9981. The proposed method provided the detection limit of l.72 x10-7 mol L-1, where the signal-to-noise ratio equaled 3.

Modyfikowaną, złotą elektrodę (Ag/L-Cys/Au CME) porównano z elektrodą niemody-fikowaną. Stosując cyklicznąwoltamperometrię (CV) stwierdzono przyśpieszenie procesów redoks hydrochinonu w elektrodzie modyfikowanej. W zakresie od 3.0 x 1O-6 do 2.0 x 10-3 mol L-1 stwierdzono liniowa zależność wysokości piku utleniania hydrochinonu od stężenia, opisaną równaniem regresji p(μA)= -0,05612 + 1,13763c &mumol L-1 r = 0.9981.Opracowana metoda charakteryzuje się granicą wykrywalności 1,72 x 10-1mol L-1,odpowiadającą stosunkowi sygnału do tlą = 3.