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Magnesium Sulfate as an Efficient and Very Cheap Reagent for the Preparation of Bis(indolyl)methanes

Hasaninejad A., Parhami A., Zare A., Khalafi-Nezhad A., Nasrolahi Shirazi A., Moosavi Zare A. R.

Polish Journal of Chemistry

2008

Vol. 82, nr 3

565-569

A simple, low cast and efficient solvent-free procedure for the preparation of bis(in -dolyl)methanes via condensation of indoles with aldehydes as well as ketones in the presence of catalytic amount of magnesium sulfate (MgSO4) is described. The reactions proceed rapidly in high yields at 50°C.