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1
Content available Photosensitive heparins
Stolarek Marta, Szczubiałka Krzysztof
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
117
2
Content available Lipid-polymer nanocarriers for cartilage regeneration
Wytrwal-Sarna Magdalena, Oclon Ewa, Kucharski Mirosław, Szmajnta Katarzyna, Kepczynski Mariusz, Szczubiałka Krzysztof
Engineering of Biomaterials
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2021
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Vol. 24, no. 163
32
3
Content available Stem cells response on photo-crosslinked heparin – bone morphogenetic proteins (BMP-2/-7) hybrid systems
Wytrwal-Sarna Magdalena, Pomorska Agata, Sekula-Stryjewska Małgorzata, Zuba-Surma Ewa, Szczubiałka Krzysztof
Engineering of Biomaterials
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2020
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Vol. 23, no. 158 spec. iss.
16
4
Content available Bone morphogenetic protein-2 adsorption on photoactive polymeric substrates
Wytrwal-Sarna Magdalena, Pomorska Agata, Sekula-Stryjewska Małgorzata, Gajos Katarzyna, Awsiuk Kamil, Sarna Michał, Zuba-Surma Ewa, Szczubiałka Krzysztof
Engineering of Biomaterials
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2020
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Vol. 23, no. 158 spec. iss.
15
5
Content available remote New long-term action insulin formulations obtained using polycations for heparin neutralization
Kamiński Kamil, Kaczor-Kamińska Marta, Irska Izabela, Popiołek Iwona, Szczubiałka Krzysztof, Nowakowska Maria
Bio-Algorithms and Med-Systems
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2019
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Vol. 15, no. 3
art. no. 20190029
EN
Phenomena that occur between an insulin and four different positively charged polymers (protamine, cationic dextran, chitosan, and poliallylamine derivatives) were studied by dynamic light scattering and fluorescence measurements (using fluorescein-labeled polymers). These processes were compared to the reaction of polycations with heparin that is responsible for the neutralization of anticoagulant activity in blood stream.The nature of polycations interaction with heparin is electrostatic, while the interaction with insulin is more complicated.We observed that the presence of zinc atoms (and its complexing by nitrogen from macromolecules) is critical for insulin suspensions formation and stability. The differences between the nature of these two reactions were revealed. The highly immunogenic action of protamine present in long-acting insulin products makes it reasonable to develop similar systems based on the nonprotein polycations.
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