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1 Polish Journal of Applied Chemistry

1 2002

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Optimization of the parameters of 2-(2-formylphenoxy)hexanoic acid cyclization. Synthesis of 2-alkylbenzofurans

Miszczyszyn M., Kwiecień H.

Polish Journal of Applied Chemistry

2002

Vol. 46, nr 1

21-29

The intramolecular cyclization of 2-(2-formylphenoxy)hexanoic acid (FPHA) to 2-butylbenzofuran under the Perkin reaction conditions has been investigated. The influence of important parameters on the 2-butylbenzofuran yield in relation to 2-(2-formylphenoxy)hexanoic acid introduced (response function) has been described by regression equations in the form of a second order polynomial. The optimum values of: acetic anhydride to FPHA molar ratio, reaction time, acetic acid to FPHA molar ratio have been determined. 2-Butylbenzofuran and some of benzene-ring-halogenated 2-alkylbenzofurans have been obtained in moderate yields from corresponding 2-(2-formylphenoxy)alkanoic acids with the use of optimal conditions.