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Grafting of oxidized carboxymethyl cellulose with hydrogen peroxide in presence of Cu(II) to chitosan and biological elucidation

Benghanem S., Chetouani A., Elkolli M., Bounekhel M., Benachour D.

Biocybernetics and Biomedical Engineering

2017

Vol. 37, no. 1

94--102

The chemical interaction of chitosan (CS) is performed in the presence of sodium carbox-ymethyl cellulose (CMC) and/or oxidized CMC. The latter is obtained by the action of H2O2/CuSO4 to generate carbonyl and carboxyl groups which were increased with CuSO4 concentration. The characterization of these new materials is made by FTIR, TGA, XRD and SEM. Examination of the hemolytic potential showed that the hydrogels were non hemolytic in nature. The hydrogels were non-toxic and blood-compatible. The antibacterial and antioxidant activities of samples were investigated.