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1

3D elastomeric scaffolds for cardiac regeneration

Sonseca A., McClain A., Puskas J. E., EL Fray M.

Engineering of Biomaterials

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2016

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Vol. 19, no. 138 spec. iss.

31

2

Synthesis and preliminary photocrosslinking studies of new photocurable poly(ester-urethane)s for biomedical applications

Skrobot J., EL Fray M.

Polish Journal of Applied Chemistry

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2009

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Vol. 53, nr 2

175-180

EN

New segmented photocurable poly(ester-urethane)s were synthesized in bulk. First, the soft segment composed of the unsaturatcd dicarboxylic fumaric acid and a renewable dimer fatty acid diol was synthesized, thus giving the ester block. The hard urethane segments were built up of aliphatic diisocyanate and different chain extenders, namely 1,4-butanediol (BD) or glycerol (GLY). The photoinitiator was introduced by solution mixing and subsequent solvent casting and light-curable films were obtained. The structure of the materials was analyzed. The FT-IR and DSC studies were performed to verify the material chcmical and phase structure.

3

Synthesis and characterization of thermal and mechanical properties of poly(glycerol sebacate) elastomers

Paturej M., EL Fray M.

Polish Journal of Applied Chemistry

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2009

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Vol. 53, nr 1

73-78

EN

In the present work, we reported on preparation of poly(glycerol sebacate) elastomer using different catalysts: p-toluenesulfonic acid monohydrate (PTS), concentrated and diluted sulphuric acid. The ATR-FTIR spectra confirmed the strong hydrogen bonding in synthesized thermoset elastomer. The investigation was focused on evaluation of mechanical and thermal properties depending from the catalytic systems used for the synthesis. Differential scanning calorimetry (DSC) studies demonstrated that synthesized elastomers are fully amorphous at 37°C. Additionally, the type of catalyst also affected the position of glass transition temperature. Derived stress- strain curves were characteristic for soft and elastic materials and demonstrated that the highest tensile strength (0.67 MPA) was obtained for system catalyzed with concentrated sulphuric acid.

4

Hydrolytic degradation of poly(ester-ether-ester) terpolymers containing hydrophilic peg and hydrophobic dimer fatty acid

Zdebiak P., EL Fray M.

Polish Journal of Applied Chemistry

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2009

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Vol. 53, nr 2

203-207

EN

The aim of the work was preparation and investigation of new multiblock terpoly(cster-cthcr cster)s (TEEE) containing phthalic acid units as in poly(butylenc tercphthalate) (PBT) (hard segments) and hydrogenated dimer fatty acid, namely dilinoleic acid sequences (DLA) as hydrophobic ester soft segments, and poly(cthylenc glycol) (PEG) as hydrophilic ether soft segments. PEG of different molar mass (1000 and 4600 g/mol) was used. Synthesis was performed in a presence of a-tocopherol as non-toxic thermal stabilizer since these materials are targeted for biomedical applications. In this work, the hydrolytic degradation process of TEEE and its influence on mechanical properties is discussed.

5

Elastomeric nanocomposites for myocardial tissune engineering

Piegat A., EL Fray M., Boccaccini A. R.

Polish Journal of Applied Chemistry

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2009

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Vol. 53, nr 2

169-174

EN

In this work we present the results of surface topography and cell adhesion investigations of new elastomeric materials composed of poly(ethylcnc tercphthalatc) (PET) hard segments and dimer fatty acid, i.e. dilinoleic acid (DLA) soft segments. 0.2 wt % TiOn nanoparticles were introduced into polymer matrix to form polymer-ceramic nanocomposite. Addition ofTi02 nanoparticles altered surface roughness and enhanced embryonic stem cells cardiomyocytes (ESC-CM) derived from mouse embryonic stem cells adhesion and spreading. The results indicate that PET/DLA and especially PET/DLA-TiOj are promising candidates for the manufacture of engineered patches with ESC-CM.