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Comparison of helical tomotherapy with multi-field intensity-modulated radiotherapy treatment plans using simultaneous integrated boost in high-risk prostate cancer

Başaran Hamit, Karaca Sibel, Koca Timur, Gündoğdu Yasemin Örs

Polish Journal of Medical Physics and Engineering

2021

Vol. 27, Iss. 2

143--149

Purpose: The aim of this study is to compare the dosimetric results of Helical Tomotherapy (HT) and Multi-field IMRT treatment plans using a Simultaneous Integrated Boost (SIB) technique in the treatment of High-Risk Prostate Cancer (HRPCa) with pelvic nodal radiation. Methods: Seventeen patients planned with HT and 7,8 and 9 fields IMRT were investigated. All plans were designed with the prescribed dose of 54.0 Gy to the PTVln while simultaneously delivering 74.0 Gy to the PTVPS in 30 fractions. Dosimetric data of PTV and OARs were compared. Results: HT gives a better CI and HI of PTVPS compared to multi-field IMRT plans. HT plans significantly improved target coverage (HT:0.95 vs multi-field IMRT: 0.52, 0.49 and 0.49 respectively, p < 0.001). Bladder mean dose(Gy) (HT: 45.6 vs multi-field IMRT: 53.6, 53.3 and 52.7 respectively, p = 0.004) and D66%(Gy) dose (HT: 35.3 vs multi-field IMRT: 46.7, 47.0 and 44.9 respectively, p = 0.006) were lower in HT. But multi-field IMRT plans significantly reduced the rectum volume receiving more than 75 Gy ; (HT V75% (%) 2.7 vs multi-field IMRT 0.8, 1.4 and 0.9 respectively, p = 0.008). HT provided better sparing of the right and left femoral head receiving a mean dose. The penile bulb and small bowel doses were the highest in HT compared with multi-field IMRT. Conclusions: HT achieved better dose distribution to target compared to multi-field IMRT. This study suggests HT as a reasonable option for the treatment of HRPCa patients.

Effect of Changing Phantom Thickness on Helical Radiotherapy Plan: Dosimetric Analysis

Karaca Sibel

Polish Journal of Medical Physics and Engineering

2019

Vol. 25, Iss. 2

121--126

Purpose: The aim of this study is to investigate the effect of changing phantom thickness on high dose region of interest (HD_ROI) and low dose ROI’s (LW_ROI’s) doses during helical radiotherapy (RT) by utilizing Adaptive RT (ART) technique. Materials and Methods: The cylindrical phantom (CP) is wrapped with different thickness boluses and scanned in the kilovoltage computed tomography (KVCT). HD_ROI and LW_ROI’s were created in contouring system and nine same plans (1.8 Gy/Fr) were made with images of different thicknesses CP. The point dose measurements were performed using ionization chamber in Helical Tomotherapy (HT) treatment machine. For detecting thickness reduction effect, CP was irradiated using bolus-designed plans and it was irradiated using without bolus plan. The opposite of this scenario was applied to determine the thickness increase. KVCT and megavoltage CT (MVCT) images were used for dose comparison. The HT Planned Adaptive Software was used to see the differences in the planning and verification doses at dose volume histograms (DVH). Results: Point dose measurements showed a 4.480% dose increase in 0.5 cm depth reduction for HD_ROI. These differences reached 8.508% in 2 cm depth and 15,279% in 5 cm depth. At the same time, a dose reduction of 0.665% was determined for a 0.5cm depth increase, a dose reduction of 1.771% was determined for a 2 cm depth increase, a dose reduction of 5.202% was determined for a 5 cm depth increase for the HD_ROI. The ART plan results show that the dose changes in the HD_ROI was greater than the LW_ROI’s. Conclusion: Phantom thicknesses change can lead to a serious dose increase or decrease in the HD_ROI and LW_ROI’s.