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Machining parameter optimization for EDM machining of Mg–RE–Zn–Zr alloy using multi-objective Passing Vehicle Search algorithm

Parsana S., Radadia N., Sheth M., Sheth N., Savsani V., Prasad N. E., Ramprabhu T.

Archives of Civil and Mechanical Engineering

2018

Vol. 18, no. 3

799--817

Mg alloys are known for their specific strength, stiffness, damping capacity, EMI shielding. Particularly, Rare earths added Mg alloys find applications in the gear box casing, transmission housing, engine mount, ribs, frames, instrument panels due to their improved corrosion resistance, pressure tightness, specific strength and creep strength. Reemergence of Mg alloys in the aircraft structural applications demands for advanced machining processes such as EDM to fabricate complex geometry parts. In this study, parametric multi-objective optimization of EDM on Mg–RE–Zn–Zr alloy is carried out using the novel meta-heuristic algorithm – Passing Vehicle Search (PVS). The input parameters considered are pulse-on (Ton), pulse-off (Toff) and peak current (A). Response surface method (RSM) is implemented through the Box–Behnken design to formulate a mathematical model for Material Removal Rate (MRR), Tool Wear Rate (TWR) and Roundness of holes. The accuracy of theoretical model has been established using the confirmation runs. Using the weighted sum method, the multi-objective PVS calculated optimal solutions for different weights to generate 2-D and surface pareto fronts. These pareto fronts were evaluated for performance determination of PVS using novel and established metrics such as spacing, spreading, hypervolume and pure diversity. The values of performance metrics indicate acceptable nature of the graphs and such analysis would facilitate better comparisons of solutions to select algorithms for optimization. Finally, decision making is illustrated with the help of level diagrams to draw up practical inferences for designing production plans and providing the best choice of machining parameters according to their preferences.

Simultaneous determination of Aspirin and Rosuvastatin Calcium in capsules by using RP-HPLC coupled with photo diode array detection

Panchal A., Sanghvi G., Vachhani A., Sheth N., Vaishnav D.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 14, iss. 2

218-230

A simple, sensitive, specific, and cost effective method for simultaneous determination of Aspirin and Rosuvastatin calcium was developed and validated in single dosage formulation. The sample solution of ASP and RSTC was prepared using methanol as a solvent. Separation of ASP and RSTC was achieved with a mobile phase consisting of 20 mM KH2PO4 : Methanol (30:70 v/v) at a flow rate of 1.0 ml/min. Separations were performed on Merck hibar 250-4.6 RP18 (5 μm) column (150 mm X 3.0 mm), using a Shimadzu Prominence HPLC system equipped with a Shimadzu SPD-20A detector, Rhenodyne 7725i injector with 20 μL loop, LC-20 AD pump, CBM-20 Alite controller and LC Solution software. Retention times of ASP and RSTC were 3.747 and 5.969 minutes respectively. Absolute recovery of ASP and RSTC was 100.3 and 100.03 % respectively. The lower limit of quantification (LLOQ) of ASP and RSTC was 0.3097 and 0.1063 ppm and lower limit of detection (LLOD) of ASP and RSTC was 0.01535 and 0.01358 ppm respectively. Linearity was established for the range of concentrations 15.00-90.0 μg/ml and 2.0-12.0 μg/ml for ASP and RSTC respectively with the coefficient of determination (R2) of 0.994 and 0.999 for both the compounds. The inter- and intra-day precision in the measurement of ASP quality control (QC) sample 75 μg/ml, were in the range 0.1-0.2 % relative standard deviation (R.S.D.) and 0.2-0.3 % R.S.D., respectively. The inter- and intra-day precision in the measurement of RST quality control (QC) sample 10 μg/ml, were in the range 0.1-0.2 % R.S.D., and 0.0-0.3 % R.S.D., respectively. The developed method would be applicable for routine quality control of ASP And RSTC in bulk as well as in pharmaceutical formulations.