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Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars

Sugiyama M., Yamashita M., Yu G., Fujie M., Ogawa K., Ozaki N., Aoki T., Mizuno S., Okada S., Tachi K., Aoshima K., Sankar U. R., Kumar B. S., Takehara Y., Sakahara H.

Journal of Automation Mobile Robotics and Intelligent Systems

2009

Vol. 3, No. 4

191-194

MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.