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Investigation of microstructure of bone tissue in mandibles of newborn rats after maternal treatment with antiretroviral drugs

Filipek J., Binkowski M., Maciejewska K., Drzazga Z., Wróbel Z.

Biocybernetics and Biomedical Engineering

2015

Vol. 35, no. 1

54--63

High-resolution imaging has become a powerful tool for measurements in clinics, laboratory and animal studies, etc. In the present study, we aimed to investigate age related changes in bone development, and the effect of two antiretroviral agents (zidovudine and indinavir), which were administered during pregnancy, on the microstructure and bone mineral density (BMD) in newborn rats (7-, 14- and 28-day-old), with the use of X-ray microcomputed tomography (XMT). Fifty-four mandible bones were collected and divided into 3 groups: group 1 and 2: newborns after maternal treatment of zidovudine and indinavir respectively, group 3: control animals. The specimens were XMT scanned with the resolution of 7 μm and with a density phantom. Histomorphometric parameters and BMD were calculated to assess bone development depending on the administered drug. A statistical analysis was carried out to compare the differences among the control, zidovudine and indinavir groups. The analysis of the microstructure revealed disturbances in the development of the bone tissue in newborn rats. Indinavir seems to have a greater impact on bone microstructure than zidovudine.

Differences in trabecular bone mechanical strength measured by the x-ray microcomputed tomography and compressive test

Binkowski M., John A., Nowak R., Bożek M., Bielecki M.

Journal of Medical Informatics & Technologies

2010

Vol. 15

163--168

The article describes the concept of measurement of the mechanical strength of trabecular bone dissected from human femoral head. When the studies are performed based on the human trabecular bone, there is a risk that correlation can be not achieved due to high discrepancy in the distribution of the bone density and mechanical properties. The compressive tests and X-ray microcomputed tomography with associated density phantom were used to deliver quantitative data. There is a conclusion that the selection of the region in the femoral head has to be performed very carefully. The region where cylinder is dissected can influence the results and produce fake data, which could not be correlated in the density of bone.