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1

Sage-modified polydimethylsiloxane applied as antibacterial wound dressing material

Sarraj Sara, Szymiczek Małgorzata, Jędrejek Dariusz, Soluch Agata, Kurpanik Roksana

Polimery

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2024

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Vol. 69, nr 1

33--43

EN

Materials based on polydimethylsiloxane have been developed with antibacterial activity and mechanical properties required for wound treatment. Sage herb (raw, modified, and polyphenol extract) was used as a filler in an amount of 5 and 10% by weight. Physicochemical, mechanical, and biological properties were examined. The results indicate a beneficial effect of sage modification on the tested properties.

PL

Na bazie polidimetylosiloksanu opracowano materiały o działaniu przeciwbakteryjnym i właściwościach mechanicznych wymaganych przy leczeniu ran. Jako napełniacz zastosowano ziele szałwii (surowe, modyfikowane i ekstrakt polifenolowy) w ilości 5 i 10% mas. Zbadano właściwości fizykochemiczne, mechaniczne i biologiczne. Wykazano korzystny wpływ modyfikacji szałwii na badane właściwości.

2

The properties of fish skin collagen films after cross-linking with tannic acid

Sionkowska Alina, Lewandowska Katarzyna, Szulc Marta, Brudzyńska Patrycja, Kulka Karolina, Piwowarski Łukasz

Engineering of Biomaterials

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2023

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vol. 26, no. 168

9--14

EN

Over the last three decades, an increasing interest in the preparation of new materials for wound healing has been observed. Collagen is a widely used biomaterial, and especially fish skin collagen is more and more popular among scientists. This study aimed to obtain thin films from native fish skin collagen and collagen cross-linked with tannic acid. Infrared spectroscopy, mechanical test, topographic imaging, and swelling test were used to characterize the features of the mentioned films. Statistical evaluation of the results was conducted with the Q-Dixon test. Infrared spectroscopy analysis showed that in the IR spectra of examined biomaterials, there are slight shifts in band positions after tannic acid cross-linking. The mechanical properties of the cross-linked material were different from those of the native collagen film. The Young’s modulus was higher for cross-linked collagen, whereas the elongation at break was lower than for pure collagen. The swelling of the collagen films increased after cross-linking with tannic acid. Swelling tests indicated that collagen cross-linked with tannic acid absorbs more water than before cross-linking. The properties of collagen films were significantly improved after tannic acid cross-linking. All alterations can be a result of collagen cross-linking by tannic acid, probably by forming hydrogen bonds between collagen and tannic acid.

3

Bioactive curdlan/agarose dressing enriched with gentamicin for infected wounds – pilot studies

Wójcik Michał, Wilczyńska Anna, Vivcharenko Vladyslav, Kazimierczak Paulina, Adaszek Łukasz, Przekora Agata

Engineering of Biomaterials

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2021

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Vol. 24, no. 160

2--7

EN

The problem of treating chronic wounds is widespread throughout the world and carries a huge cost. Biomaterials engineering tries to solve this problem by creating innovative bioactive dressings dedicated to specific types of wounds. Both synthetic and natural polymers are the main base to produce wound dressings. Biopolymers have the advantage over synthetic polymers by being more biocompatible, non-toxic, biodegradable, and eco-friendly. The aim of this work was to produce a bioactive biomaterial based on natural polymers with potential applications to manage chronic highly exuding and infected wounds. A newly developed method for chemical synthesis of the curdlan/agarose biomaterial at high temperature combined with freeze-drying process resulted in a superabsorbent dressing material with antibiotic immobilized. The obtained biomaterial was subjected to basic microbiological in vitro tests and a cytotoxicity assay according to ISO 10993-5. Moreover, the experimental treatment of the infected wound in a veterinary patient was performed using the developed material. Based on the conducted research, it was proved that the produced dressing is not toxic to normal human skin fibroblasts. An additional advantage of the biomaterial is its ability to inhibit the growth of harmful microorganisms, such as Staphylococcus aureus and Pseudomonas aeruginosa. Furthermore, the experimental treatment confirmed the validity of using the produced biomaterial as a dressing dedicated to the treatment of difficult-to-heal infected wounds. To summarize, the produced biomaterial possesses great potential to be used as a wound dressing for infected wounds.

4

Porous poly(lactic acid) based fibres as drug carriers in active dressings

Dzierzkowska Ewa, Ścisłowska-Czarnecka Anna, Matwally Sara, Romaniszyn Dorota, Chadzińska Magdalena, Stodolak-Zych Ewa

Acta of Bioengineering and Biomechanics

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2020

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Vol. 22, no. 2

185--197

EN

Purpose: The polymeric porous surface of fibres (PLA) may influence the kinetics of release of biologically active compounds (gentamicin, G and ethacridine lactate, R) affecting development of a bacterial biofilm. Methods: The porous fibres with different morphology were manufactured by the electrospinning method from ternary systems composed of PLA and selected solvents. Fibres morphology was examined using a scanning electron microscopy (SEM), their structure was analyzed by FT-IR ATR spectroscopy and differential scanning calorimetry (DSC). Changes in the drug release profile were measured using ICP/UV-Vis methods and the resulting bactericidal or bacteriostatic properties were tested by two-layer disk diffusion test in relation to various drug incorporation methods. Results: The porous fibres can be applied to produce drug-bearing membranes. The spectroscopic studies confirmed incorporation of gentamicin into the fibres and the presence of ethacridine lactate on their surface. Bimodal fibres distribution (P3) promoted faster release of gentamicin and ethacridine lactate from P3G and P3R materials. The electrospinning process coupled with the vapor induced phase separation influenced the glass transition temperature of the porous polymer fibres. The pre/post-electrospinning modification influenced the glass transition, maximum temperature of cold crystallization and melting point of the porous membrane, compared to the neat polymer. The polylactide fibres with gentamicin showed strong bactericidal effect on Gram-positive bacteria, while fibres with ethacridine lactate were bacteriostatic. Conclusions: The obtained fibres with complex surface morphology can be used as a membrane in active dressings as they make it possible to control the release profile of the active compounds.

5

Biological Dressings Based on Natural Polymers

Kucharska M., Brzoza-Malczewska K., Wiśniewska-Wrona M., Pałys B., Struszczyk M. H., Cichecka M., Wilbik-Hałgas B., Karuga-Kuźniewska E., Paluch D., Rybak Z.

Fibres & Textiles in Eastern Europe

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2016

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Vol. 24, no. 6 (120)

170--174

EN

The article presents a method for producing a IV generation hemostatic dressing in the form of powder consisted of fibrous, which ensures a high level of security in application. The dressing material was developed on the basis of natural polymers of the polysaccharide group such as chitosan and calcium sodium alginate in the form of micro- and nanofibrids. The dressing structure, utility properties and biocompatibility (cytotoxicity, irritation and sensitization) were studied.

PL

W artykule przedstawiono metodę wytwarzania hemostatycznego opatrunku IV generacji, który gwarantuje wysoki stopień bezpieczeństwa przy aplikacji. Opatrunek posiada formę proszku fibrydowego. Do opracowania materiału opatrunkowego wykorzystane zostały polimery naturalne z grupy polisacharydów takie jak chitozan i alginian sodowo-wapniowy. Opatrunek został poddany badaniom strukturalnym, właściwościom użytkowym oraz ocenie biozgodności (cytotoksyczność, właściwości drażniące i uczulające).

6

Medical and healthcare devices: materials perspective

Hasan M. K, Anand S. C

Journal of Education and Technical Sciences

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2014

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Vol. 1, nr 1

10-13

EN

People are special. The importance and need for the research and development into medical and healthcare devices can never be overstated. In the 21st century, medical and healthcare devices play a more vital role in our lives than ever before. A wide range of materials are being used for producing numerous medical and healthcare devices for a variety of end use. In this manuscript, historical development of wound care dressings and products are reviewed. The characteristics and requirements of modern wound dressings are summarized. A core part is devoted to the description of the materials used in medical and healthcare devices. Selected synthetic polymers are listed with their applications in medical and healthcare devices. The advantages and limitations of fibres, metals, ceramics and composites are denoted. Textile structures are highlighted with their applications in medical and healthcare devices.

7

On the preparation and characteristics of polymer systems for wound dressings

Greidane J., Kalnins M., Dzene A., Tupureina V.

Prace Naukowe Instytutu Inżynierii Ochrony Środowiska Politechniki Wrocławskiej. Konferencje

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2006

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Vol. 81, nr 12

199-203

EN

Possibility to use different kind of polymers for the development of wound dressings was analyzed in the abstract. Properties of different polymers used for wound dressings are analyzed in the abstract. The overview of recent literature about wound dressings is represented. On the basis of information our research with poly (vinyl alcohol) gels has been started. The first results are presented in this abstract. Different materials may be used for wounds protection but assessment of wound must be done before choosing them. Some conditions are important for burn treatment and wound dressing use: maintain vapour and moisture permeability characteristics similar to skin; prevent infection; provide necessary adherence between wound and wound dressing; be compatible and ensure physical structure in wet state.

PL

Przedstawiono obecny stan wiedzy literaturowej na temat opatrunków. Wyszczególniono i opisano właściwości materiałów polimerowych stosowanych do opatrywania ran. Zostały tez przedstawione wyniki badań dotyczących żelów na bazie polialkoholu winylowego.