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EN
On separate days, 6 highly trained participants performed psychomotor tests while breathing for 60 min 3 carbon dioxide (CO2) mixtures (room air, 3% CO2, or 4% CO2) prior to, between, and following two 15- min treadmill exercise bouts (70% VO2max). Each individual was extensively practiced (at least 4 days) before testing began, and both gas conditions and order of tasks were counterbalanced. Results showed physiological reactions and work-related psychomotor effects, but no effects of gas concentration on addition, multiplication, grammatical reasoning, or dynamic postural balance. These findings help define behavioral toxicity levels and support a re-evaluation of existing standards for the maximum allowable concentrations (also emergency and continuous exposure guidance levels) of CO2. This research explored the selection of psychometric instruments of sufficient sensitivity and reliability to detect subtle changes in performance caused by exposure to low levels of environmental stress, in this case differential levels of CO2 in the inspired air.
EN
Physicochemical techniques used for evaluating the pulmonary surfactant (PS) quality are discussed as methods useful in assessing toxicity of inhaled gases and particles. Two standard devices, Langmuir-Wilhelmy film balance and pulsating bubble apparatus, are presented in detail, and the measured results of interaction between sulfuric acid and 2 models of PS material are analyzed. The evident decrease in surface activity of the pulmonary surfactant after its contact with the acid at concentrations approaching 0.001 M may be considered as an indicator of the adverse effect, which can result in several health problems. The presented approach can be used as a method of assessing pulmonary toxicity of any substances present in the breathing air.
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