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Zastosowania systemów uwalniania wankomycyny do regeneracji tkanki kostnej

Träger Dominika, Niziołek Karina

Inżynieria Materiałowa

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2023

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Vol. 44, nr 4

18--24

PL

Wankomycyna (VA) jest szeroko stosowanym glikopeptydowym antybiotykiem, o bardzo skutecznym działaniu bakteriobójczym/bakteriostatycznym. Jest stosowana profilaktycznie przed operacjami, po zabiegach lub w ich trakcie wraz z wszczepianym implantem celem zahamowania namnażania się bakterii i zapobiegania infekcji. Pomimo skutecznego działania bakteriobójczego, nieostrożne i niewłaściwe podanie antybiotyku może skutkować toksycznym działaniem prowadzącym do stałych uszkodzeń w ciele. W przeglądzie przedstawiono przykłady połączenia VA z implantami, które pozwalają na precyzyjne dostarczenie leku oraz kontrolę nad czasem jego uwalniania, wspomagając tym samym regenerację tkanki kostnej

EN

Vancomycin (VA) is a widely used glycopeptide antibiotic with highly effective bactericidal/bacteriostatic activity. It is used prophylactically before, after, or during surgery along with an implant to inhibit bacterial proliferation and prevent infection. Despite its effective antibacterial effect, careless and inappropriate administration of the antibiotic can result in toxicity leading to permanent damage in the body. The review provides examples of combining VA with implants that allow precise delivery of the drug and control over the timing of its release, thereby aiding bone tissue regeneration

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Badanie oddziaływania wankomycyny z fragmentem peptydoglikanu ściany komórkowej bakterii

Samaszko-Fiertek J., Ślusarz R., Madaj J.

Wiadomości Chemiczne

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2015

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[Z] 69, 7-8

491--511

EN

Unfortunately, despite of work involved in understanding of the mechanism of bacterial virulence, especially Staphylococcus aureus, it has not been developed effective therapy against this bacteria. The first antibiotic used against this bacteria was penicillin, which was discovered by Alexander Fleming in 1928. A new generation of drugs introduced into therapy against Staphylococcus aureus and other Gram-positive bacteria are glycopeptide antibiotics. The most widespread and most commonly used are vancomycin and teicoplanin, discovered respectively in 1956 and 1978. As a result of frequent use of vancomycin VISA (ang. Vancomycin-intermediate Staphylococcus aureus) and VRSA (ang. Vancomycin-resistant Staphylococcus aureus) strains were discovered. The mechanism of action of this antibiotic based on the inhibition of the biosynthesis of bacterial cell wall peptidoglycan fragment. Forming stabilized by hydrogen bonds complex with terminal fragment of peptidoglycan (dipeptide d-Ala-d-Ala) vancomycin prevents its further crosslinking [2] (Fig. 1). However, in recent years other theories of the mechanism of action of glycopeptide antibiotics against Gram-positive bacteria were presented it seems to be crucial to find methods of selection of new antibiotics and for this purpose standard techniques of the analysis, including isothermal titration calorimetry (ITC) [3], nuclear magnetic resonance spectroscopy (NMR) [8–15], high performance liquid chromatography (HPLC) [16], capillary electrophoresis [17] or self-assembled monolayers (SAMs) [22] are used. Discovering new methods for studying of interaction between vancomycin and Gram-positive bacterial cell wall allows use it as a new technique for rapid selection of potential new antibiotics, including glycopeptide derivatives.

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Wankomycyna i jej chemiczne modyfikacje

Łakomiec A., Samaszko J., Madaj J.

Wiadomości Chemiczne

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2007

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[Z] 61, 3-4

231-245

EN

Antibiotics, such as penicillin or streptomycin, are substances produced by or derived from certain fungi or bacteria, that can destroy or inhibit the growth of other microorganisms. Antibiotics are widely used in the prevention and treatment of infectious diseases. Glycopeptide antibiotics are a class of antibiotic drugs. They consist of a glycosylated cyclic or polycyclic nonribosomal peptide. Important glycopeptide antibiotics include vancomycin, teicoplanin, ramoplanin, and decaplanin. This class of drugs inhibits the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis. Glycopeptides exhibit a narrow spectrum of activity as principally effective against gram positive cocci. They are the last line of effective defense against MRSA and multiresistant enterococci for patients who are critically ill. At the beginning of the 90' there started a large scale research program for finding glycopeptide antibiotics with optimized properties. These studes resulted in the discovery of the hemi-synthetic compounds (1996 oritavancin) which have lower toxicity than vancomycin.