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1

Vascular structure of the earliest shark teeth

Martínez-Pérez C., Martín-Lazaro A., Ferrón H. G., Kirstein M., Donoghue P. C. J., Botella H.

Acta Geologica Polonica

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2018

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Vol. 68, no. 3

457--465

EN

Here we use synchrotron tomography to characterise dental vasculature in the oldest known tooth-bearing sharks, Leonodus carlsi Mader, 1986 and Celtiberina maderi Wang, 1993. Three dimensional reconstruction of the vascular system and microstructure of both taxa revealed a complex and dense network of canals, including horizontal, ascending and secondary bifurcated canals, as well as histological features consistent with an osteodont histotype. However, L. carlsi and C. maderi also exhibit significant morphological differences, showing Leonodus a typical diplodont tooth morphology with a linguo-labially elongated base, that contrast with Celtiberina’s teeth that show a single conical cusp curved lingually with a week developed flat base mesio-distally extended, perhaps reflecting distant relationship. These data are compatible with a pre-Devonian diversification of the two main tooth types traditionally recognised in Palaeozoic sharks (i.e., “cladodont” vs “diplodont”). Finally, our data demonstrate that existing dental classification schemes based on styles of vascularisation are over-simplified, especially when Palaeozoic taxa are considered.

2

Computer modelling of vascular systems

Krętowski M., Bézy-Wendling J.

TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

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2004

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Vol. 8, No 2

223-229

EN

A model of the vascular system perfusing an internal organ is presented in the paper. The system's development is driven by the increasing needs of growing tissue. The modelled network consists of 2 or 3 (in the case of the liver) vascular trees connected on the macro-cell level. Each appearance of a new macro-cell activates an angiogenic process. The geometry of newly formed vessels is determined as a result of local optimization of the bifurcation volume. The model can simulate modifications of the vascular network caused by pathological processes.

3

Endothelial cell responses to fluid shear stress

Kamiya A.

Biocybernetics and Biomedical Engineering

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2000

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Vol. 20, no. 3

21-33

EN

Implications of vascular endothelial cell (EC) responses to flow-oriented wall shear stress are outlined from the bioengineering viewpoint. These responses regulate the adaptive remodeling of the vascular system including capilIary networks, in a negative feedback mechanism maintaining the shear stress level constant. The preserved set point of the stress is selected so as to optimize the mass transport function of the system. To initiate such shear-dependent responses, EC has a mechano-sensor conjugated with second messengers, one of which is cytoplasmic Ca(2+) transient. The evidence that wall shear stress is the real factor inducing the transient, is visualized from an in vitro flow loading experiment to cultured ECs using mediums differing in viscosity.

PL

W artykule przedstawiono implikacje występowania reakcji komórki śródbłonka na naprężenia ścinające w ścianie naczynia, związane z przepływem płynu. Reakcje te kontrolują adaptację systemu naczyń krwionośnych, łącznie z siecią kapilar, utrzymując naprężenia ścinające na stałym poziomie za pomocą mechanizmu ujemnego sprzężenia zwrotnego. Zadany poziom naprężeń jest tak dobrany, aby optymalizować funkcję transportu masowego układu naczyniowego. W celu inicjacji reakcji, zależnej od poziomu naprężeń ścinających, komórki nabłonka wykorzystują mechano-sensor połączony z innymi "przekaźnikami", z których jednym jest transport wapnia. Dowód, że naprężenia ścinające w ściance naczyń są czynnikiem uruchamiającym ten "transport" jest widoczny podczas badań in vitro mechanizmu przepływu medium o różnej lepkości w hodowli komórek śródbłonka.