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1

Modelowanie i walidacja wytrzymałościowa przegrody budowlanej w zabudowie szkieletowej

Gołębiowski Łukasz, Teodorczyk Michał, Fedorczyk Zbigniew, Piekarczuk Artur

Inżynieria i Budownictwo

|

2024

|

R. 80, nr 4

239--242

PL

W artykule zaprezentowano badania doświadczalne i analizy numeryczne przegród w zabudowie szkieletowej. Przedmiotem analizy były elementy badawcze reprezentujące fragment przegrody składającej się z profili stalowych zimnogiętych oraz okładzin gipsowo-kartonowych. Przeprowadzono test wytrzymałości w układzie czteropunktowego zginania, w którym rejestrowano ciągły zapis obciążenia od przemieszczenia elementu. Badania prowadzono do momentu zniszczenia. Następnie opracowano model obliczeniowy bazujący na metodzie elementów skończonych (MES), odwzorowujący doświadczenie. Wyniki badań uzyskane w doświadczalnym teście wytrzymałościowym porównano z wynikami uzyskanymi w analizie numerycznej. Przeprowadzona walidacja modelu numerycznego wykazała dużą zgodność w zakresie charakterystyki obciążenia od przemieszczenia. Zastosowanie analiz numerycznych stanowi alternatywę dla czasochłonnych badań doświadczalnych przy szacowaniu przemieszczeń przegród w zabudowie szkieletowej.

EN

The article presents experimental research and numerical analysis of a building partition in frame construction. The subject of the analysis were sections of the building partition consisting of cold-bent steel profiles and plasterboard cladding. The experiment was carried out using a four-point bending test and recording a continuous load-displacement curve until failure. Next, a computational model based on the finite element method was developed to simulate the experiment. The results from the experimental tests were then compared with that obtained from the numerical analysis. The validation of the numerical model demonstrated a high level of agreement in terms of load-displacement characteristics. The use of numerical analyses provides an alternative to time-consuming experimental tests for estimating displacements of building partitions in frame construction.

2

Towards ensuring software interoperability between deep learning frameworks

Lee Youn Kyu, Park Seong Hee, Lim Min Young, Lee Soo-Hyun, Jeong Jongwook

Journal of Artificial Intelligence and Soft Computing Research

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2023

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Vol. 13, No. 4

215--228

EN

With the widespread of systems incorporating multiple deep learning models, ensuring interoperability between target models has become essential. However, due to the unreliable performance of existing model conversion solutions, it is still challenging to ensure interoperability between the models developed on different deep learning frameworks. In this paper, we propose a systematic method for verifying interoperability between pre- and post-conversion deep learning models based on the validation and verification approach. Our proposed method ensures interoperability by conducting a series of systematic verifications from multiple perspectives. The case study confirmed that our method successfully discovered the interoperability issues that have been reported in deep learning model conversions.

3

Novel rheological modelling of thermosets and unidirectional monotropic fibre-reinforced thermoset matrix composites

Klasztorny Marian, Nycz Daniel B.

Composites Theory and Practice

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2023

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R. 23, nr 1

3--21

EN

A refined, fully analytical rheological modelling of thermosetting polymers and unidirectional monotropic fibre-reinforced thermoset matrix (UFRT) composites is presented. New polymers and composites under normal conditions, fully relaxed from curing and post-curing stresses, are modelled. The theory includes quasi-static short-term/medium-term/long-term reversible rheological processes. Thermosets are isotropic materials exhibiting linearly viscoelastic shear strains and linearly elastic bulk strains. Fibres are monotropic (transversely isotropic) and linearly elastic materials. A generic function well reproducing the viscoelastic characteristics of thermosets and UFRT composites is a Mittag-Leffler fractional exponential function in an integral form. Coupled/uncoupled standard/inverse constitutive equations of linear rheology are formulated for thermosets and UFRT composites. The equations are mutually analytically transformable. New rheological models (coded H-R/H) for thermosets and UFRT composites are described by the smallest possible number of material constants. The thermoset is described by two independent elastic constants and three independent viscoelastic constants. The homogenized UFRT composite is described by five independent elastic constants and four independent viscoelastic constants, whereby two visco-elastic constants are common to the matrix and the composite. An improved homogenization theory of UFRT composites, based on analytical solutions of the selected tasks of the theory of linear elasticity, is formulated for monotropic fibres and positively validated experimentally. The viscoelastic constants of the thermoset are calculated analytically in an iterative loop using a long-term unidirectional tension creep experimental test. The viscoelastic constants of the UFRT composite are calculated analytically employing H-R/H shear/quasi-shear storage compliances and VECP (the viscoelastic-elastic correspondence principle) shear/quasi-shear storage compliances. The H-R/H rheological model was validated numerically for selected UFRT composites. The validation tests were performed on the enhanced reliability UFRT composites reported by Soden, Hinton, and Kaddour (Composites Science and Technology, 1998, 2002).

4

Experimental and Numerical Comparison of Lead-Free and Lead-Containing Brasses for Fixture Application

Radzioch Grzegorz, Bartocha Dariusz, Kondracki Marcin

Archives of Foundry Engineering

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2023

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Vol. 23, iss. 3

124--132

EN

A comparative analysis of brasses alloys, namely lead-free CuZn (CB771) and lead containing CuZn (CB770), was conducted in this article. The results of the comparative analysis and experimental investigations aimed to provide comprehensive knowledge about the thermophysical properties and solidification characteristics of these alloys. Thermodynamic simulations using Thermo-Calc software and modifications in the chemical composition of the CB771 alloy were employed to approximate its characteristics to those of the lead containing CuZn alloy. Thermal-derivative analysis of the alloys and a technological trial were carried out to determine their solidification characteristics, fluidity, and reproducibility. The casting trials were conducted under identical conditions, and the results were compared for a comprehensive analysis. Additionally, a solidification process simulation was performed using MagmaSoft software to match the thermophysical properties. The aim of this research was to achieve maximum consistency between the simulation results and experimental investigations.

5

Narzędzia statystyczne w procesie walidacji

Konieczka Piotr

Analityka : nauka i praktyka

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2023

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nr 3

32-34

PL

Poza typowymi narzędziami w procesie walidacji, takimi jak roztwory i próbki wzorcowe, certyfikowane materiały odniesienia, próbki ślepe, próbki wzbogacone w analit, to właśnie statystyka matematyczna jest tym narzędziem, dzięki któremu możliwe jest określenie zarówno istotności różnic między wartościami, zgodności wartości z założonymi, zależności między sygnałem a zawartością.

6

Validation and calibration of SWAT model for Kollur River Basin, Kundapura Taluk, Udupi District, Karnataka, India

Poojashree Bommetty Purushotham, Peladdy Bhavya, Suresha Kothegala Javaregowda

Acta Geophysica

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2023

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Vol. 71, no. 2

837--853

EN

The present research work has been carried out for the Kollur River Basin, Kundapura Taluk of Udupi District of Karnataka. Kollur River is tributaries of Chakra and Souparnika Rivers. The problem of seawater getting mixed with underground water tables has become acute in many gram panchayats like Maravanthe and Senapura, located near the seashore. Villages like Vandse and Chittur, situated some distance away from the sea, have another problem on hand. The drinking water sources of these villages have dried up due to the depletion of the water table. To understand the hydrology of this complex landscape, the SWAT-CUP model was calibrated and validated using the SUFI-2, considering 14 important hydrologic parameters based on literature sources. The SUFI-2 tool employs stochastic calibration, which recognizes and expresses model errors and uncertainties as ranges account for all underlying variables, conceptual framework, parameters, and observed values. Our watershed model has eight sub-basins and 126 Hydrological Response Units (HRU) to simulate hydrological processes. Climate data from 2007 to 2021 revealed that the most precipitation occurred from June to September, with a maximum of 789 mm in June and a low of 0 mm in January. The hydrographs of 95 PPU plots were obtained from single iterations (500 simulations). The p-factor and r-factor were found to be 0.15 and 1.59, respectively. The accuracy of the simulation findings between observed and model-generated streamflow values was satisfactory. The SWAT-CUP enhanced streamflow models by lowering parameter uncertainty. It can be concluded that less sensitive parameters require more time to reduce the uncertainty than more sensitive values due to wider confidential intervals.

7

Sediment yield modeling in Awash Melkasa dam watershed, upper Awash River basin, Ethiopia

Daba Bayisa Itana, Demissie Tamene Adugna, Tufa Fayera Gudu

Acta Geophysica

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2023

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Vol. 71, no. 5

2287--2306

EN

Soil erosion may be a main problem within the Ethiopian highlands. The Awash River basin is one among the Ethiopian highlands suffering from a high rate of surface erosion. Sediment inflow rates of reservoirs and spatial distribution of sediment yield (SY) are required at the sub-basin level to develop alternative watershed management practices. Hence, this study aimed toward estimating SY within the upper Awash River by using the soil and water assessment tool. The spatial, weather, hydrological, reservoir input, and water withdrawal data were collected and analyzed. The model had adjusted and verified for both flow and sediment. The graphical comparison and statistical indicators, coefficient of determination (R2), Nash–Sutcliffe efficiency (NSE), root-mean-square error standard deviation ratio (RSR) and percent bias (PBIAS) had used to evaluate the model's performance. Monthly streamflow and SY estimates were found to be reliable (R2 = 0.78–0.83, NSE = 0.75–0.82, RSR = 0.43–0.5 and PBIAS = 0.1–8.8) based on the model calibration and validation results. After calibration, the simulated average annual SY estimated was 22,109.5 t yr-1at the outlet, with an average spatial distribution of 6.52 t ha-1 yr-1. The model prediction outcomes showed that about 26.16% of the Awash Melkasa watershed, located in southwestern direction, is an erosion-prone area with a mean annual SY ranging from 10 to 18.54 t ha-1 yr-1execiding tolerable soil loss. These sub-basins need prior mitigation measures to reduce soil losses from the catchment.

8

Quality risk assessment and DoE – Practiced validated stability-indicating chromatographic method for quantification of Rivaroxaban in bulk and tablet dosage form

Palandurkar Kamlesh, Bhandre Richie, Boddu Sai H. S., Harde Minal, Lakade Sameer, Kandekar Ujjwala, Waghmare Prashant

Acta Chromatographica

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2023

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Vol. 35, no. 1

10--20

EN

A systematic DoE and Analytical Quality by Design (AQbD) approach was utilized for the development and validation of a novel stability indicating high-performance thin–layer chromatographic (HPTLC) method for Rivaroxaban (RBN) estimation in bulk and marketed formulation. A D-optimal design was used to screen the effect of solvents, volume of solvents, time from spotting to development and time for development to scanning. ANOVA results and Pareto chart revealed that toluene, methanol, water and saturation time had an impact on retention time. The critical method and material attributes were further screened by Box-Behnken design (BBD) to achieve optimal chromatographic condition. A stress degradation study was carried out and structure of major alkaline degradant was elaborated. According to the design space, a control strategy was used with toluene: methanol: water (6:2:2) and the saturation time was 15 min. A retention factor (RF) of 0.59 ± 0.05 was achieved for RBN using chromatographic plate precoated with silica gel at detection wavelength 282 nm with optimized conditions. The linear calibration curve was achieved in the concentration range of 200–1,200 ng/band with r2 > 0.998 suggesting good coordination between analyte concentration and peak areas. The quadratic model was demonstrated as the best fit model and no interaction was noted between CMAs. The optimized HPTLC method was validated critically as stated in International Conference on Harmonization (ICH) Q2 (R1) guideline and implemented successfully for stress degradation study of RBN. The developed HPTLC method obtained through AQbD application was potentially able to resolve all degradants of RBN achieved through forced degradation study. The obtained results demonstrate that a scientific AQbD approach implementation in HPTLC method development and stress degradation study drastically minimizes the number of trials in experiments, ultimately time and cost of analysis could be minimized.

9

Development and validation of RP-HPLC method for quantification of trace levels of topical corticosteroids in ambiphilic cream

Ivković Branka, Crevar Milkica, Cvetanović Anka, Ubavkić Katarina, Marković Bojan

Acta Chromatographica

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2023

|

Vol. 35, no. 1

46--51

EN

Corticosteroids are anti-inflammatory and immunosuppressant drugs. Topical corticosteroids formulations (ointments, creams, gels) are used in the treatment of different types of dermatitis and urticaria. Considering their therapeutic and whitening effects, they are frequently used for counterfeiting of cosmetic products. Corticosteroids can cause different local and systemic side effects. HPLC method is often chosen for their analysis, because it is selective, sensitive, precise, simple and fast. The aim of this study was optimization and validation of RP-HPLC method with UV detection for determination of trace levels of corticosteroids in ambiphilic creams. This method is used for qualitative and quantitative analysis of evaluated corticosteroids. Mometasone furoate, hydrocortisone acetate, fluocinonide, fluocinolone acetonide, betamethasone, betamethasone dipropionate and triamcinolone acetonide were evaluated. Separation was performed on Inertsil® ODS-3V 250 × 4.6 mm, 5 μm chromatographic column. Mobile phase was mixture of acetonitrile and water 50:50 (v/v) with gradient elution and flow rate 1 mL min⁻¹. Column temperature was held on 40 °C and UV detection was performed at 240 nm. Selectivity, linearity, accuracy, precision and limit of quantification (LOQ) were evaluated. Method is selective because ambiphilic cream base peaks and corticosteroids peaks were not overlapping. Linearity was confirmed since correlation coefficient was 1 for all compounds. Accuracy and precision were evaluated for hydrocortisone acetate and betamethasone dipropionate. Determined Recovery values were in range of 70–130%. Both RSD values (21.46% and 9.59%) were lower than 30%. Method is highly sensitive since LOQ concentrations were in ng mL⁻¹ range. All evaluated parameters of validation were in accordance with regulatory requirements. Validated RP-HPLC method can be used for qualitative and quantitative analysis of selected corticosteroids in ambiphilic creams.

10

Comparative study of performances of UHPLC-MS/MS and HPLC/UV methods for analysis of ziprasidone and its main impurities

Čarapić Marija, Marković Bojan, Pavlovic Milena, Agbaba Danica, Nikolic Katarina

Acta Chromatographica

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2023

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Vol. 35, no. 3

260--271

EN

Ziprasidone is the second generation antipsychotic drug with unique multipotent G-protein-coupled (GPCR) receptor binding profile. Since ziprasidone is a highly lipophilic and unstable compound, development of efficient method for a concurrent assay of ziprasidone and its main impurities was a very challenging task. The UHPLC-MS/MS method that we developed for simultaneous determination of ziprasidone and its main impurities (BITP, Chloroethyl-chloroindolinone, Zip-oxide, Zip-dimer, and Zip-BIT) was compared with some other related HPLC-UV methods of our own and other authorship. An increase of the mobile phase pH value from 2.5 to 4.7 units in the examined analytical methods influenced elution order of the investigated compounds. It was found out that the UHPLC-MS/MS method is more selective and sensitive than the earlier developed HPLC-UV method. Similar to our earlier HPLC-UV method, the UHPLC-MS/MS method is linear with a correlation coefficient (r) above 0.99 for all the analysed compounds, but with a negligibly lower precision and accuracy. Finally, with shorter analysis time, smaller column size and reduction of solvent consumption, UHPLC-MS/MS is assumed as a greener method than HPLC-UV for the ziprasidone purity assay. After transfer of the UHPLC-MS/MS method to the UHPLC-DAD system, suitability of the UHPLC-DAD method for routine control of ziprasidone and its main impurities is examined and confirmed based on the retained good selectivity, resolution and short analysis time.

11

A new simple liquid chromatographic assay for gentamicin in presence of methylparaben and propylparaben

Ivković Branka, Milutinović Ivana, Čudina Olivera, Marković Bojan

Acta Chromatographica

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2023

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Vol. 35, no. 1

81--87

EN

Gentamicin sulfate is a potent broad spectrum aminoglycoside antibiotic which is used against Gram-positive and Gram-negative bacteria. A simple, isocratic HPLC method for separation, identification and determination of gentamicin and parabens (methylparaben and propylparaben) was developed and validated. To our knowledge there is no report about simultaneous determination of those three analytes in pharmaceutical products. The optimum chromatographic conditions were achieved on CN column with a mobile phase consisting of 0.15% triethylamine in 10 mM KH₂PO₄ aqueous solution (final pH 3.0 adjusted with H₃PO₄) and methanol in the ratio 70:30 (v/v), providing selective quantification of analytes within 5 min. The method was successfully validated according to ICH guidelines acceptance criteria in terms of selectivity, linearity, accuracy, precision and robustness. The linearity of the method was proved in defined concentrations ranges for gentamicin (0.32–1.04 mg mL⁻¹), methylparaben (0.0072–0.0234 mg mL⁻¹) and propylparaben (0.0008–0.0026 mg mL⁻¹). Relative standard deviations calculated for all analytes in precision testing were <2% (analysis repeatability) and <3% (intermediate precision). Recovery values were between 98.87% and 101.67%. Chromatographic parameters are not significantly influenced by small variations of column temperature, pH and molarity of KH₂PO₄. Finally, the method was successfully applied for quantitative determination of gentamicin and parabens in commercially available solution for injection. Proposed HPLC method is found to be promising in terms of simplicity, analysis times and non-use of derivatization and ion-pair agents.

12

Calibration and validation of a macroscopic traffic flow model based on platoon dispersion and queue propagation

Storani Facundo, di Pace Roberta, de Luca Stefano, Memoli Silvio

Zeszyty Naukowe. Transport / Politechnika Śląska

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2022

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z. 114

155--167

EN

This paper proposes a preliminary calibration and validation of a macroscopic traffic flow model for signalised junctions. In fact, on the network signal setting design problem, a reliable modelling approach must be adopted to acknowledge the traffic flow effects, considering two phenomena: queue dispersion and spillback. The proposed model is an extension of the space-time discrete Cell Transmission Model (CTM), which can simulate dispersion and horizontal queue. This preliminary calibration and validation use real-world data collected on an arterial of the city of Salerno (south of Italy). Results showed that the estimated parameters are consistent with the literature.

13

Study of flow pattern on a hydrofoil with structural and profile modification

Chada Jithendra Sai Raja, Rao B. S. V. Rama

Journal of Mechanical and Energy Engineering

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2022

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Vol. 6, No 1

27--31

EN

Moving through water takes much more effort than walking through air, and this explains why ships travel much more slowly than automobiles and aircraft. Water is almost 1000 times denser than air, so most of the energy produced by a boat is taken up by dragging (water resistance). Hydrofoils travel much more quickly than ordinary boats, not by pushing through water but by raising the hull (the main body) of the boat upward so it can glide above the waves. Hydrofoil is one of the typical factors that affect the vortex structure and flow characteristics of hydraulic machinery. In order to enhance the utilisation efficiency of hydraulic machinery in marine energy, parallel grooves are proposed and applied to the hydrofoil. Following that, a numerical analysis is performed using the SST k- turbulence model, and the effects of the hydrofoil profile, the angle of attack and the flow are investigated. The profiles of NACA 0066, NACA 8412, NACA M2 and RAE 104 are considered for the study. The performance is analysed based on the lift to drag ratio. The best model from this is given with surface modification and the flow study is carried out at different angles of attack. The modified profile of NACA 8412 with parallel groves has shown the highest lift to drag ratio at a 12 degree angle of attack.

14

Using Bayesian methods in the task of modeling the patients' pharmacoresistance development

Voronenko Mariia A., Zhunissova Ulzhalgas M., Smailova Saule S., Lytvynenko Luidmila N., Savina Nataliia B., Mulesa Pavlo P., Lytvynenko Volodymyr

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska

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2022

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T. 12, nr 2

77--82

EN

In this paper, we propose a methodology for using static Bayesian networks (BN) in modeling the development of pharmacoresistance in patients with a diagnosis of epilepsy. Methods for constructing the structure of a static BN, their parametric training, validation, sensitivity analysis and “What-if” scenario analysis are considered. The model was designed in collaboration with expert doctors, as well as expert pharmacologists in the selection and quantification of input and output variables.

PL

W niniejszej pracy zaproponowano metodologię wykorzystania statycznych sieci bayesowskich (BN) w modelowaniu rozwoju farmakooporności u pacjentów z rozpoznaniem padaczki. Rozważane są metody konstruowania struktury statycznej BN, jej parametrycznego treningu, walidacji, analizy wrażliwości i analizy scenariuszy "co-jeśli". Model został zaprojektowany we współpracy z ekspertami – lekarzami, a także ekspertami – farmakologami w zakresie doboru i kwantyfikacji zmiennych wejściowych i wyjściowych.

15

Niepotrzebne walidatory?

Czekaj Damian

Geodeta : magazyn geoinformacyjny

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2022

|

nr 8

30

16

Design optimization of the Petri net-based production process supported by additive manufacturing technologies

Patalas-Maliszewska Justyna, Wiśniewski Remigiusz, Topczak Marcin, Wojnakowski Marcin

Bulletin of the Polish Academy of Sciences. Technical Sciences

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2022

|

Vol. 70, nr 2

art. no. e140693

EN

In the era of smart manufacturing and Industry 4.0, the rapid development of modelling in production processes results in the implementation of new techniques, such as additive manufacturing (AM) technologies. However, large investments in the devices in the field of AM technologies require prior analysis to identify the possibilities of improving the production process flow. This paper proposes a new approach to determine and optimize the production process flow with improvements made by the AM technologies through the application of the Petri net theory. The existing production process is specified by a Petri net model and optimized by AM technology. The modified version of the system is verified and validated by the set of analytic methods safeguarding against the formal errors, deadlocks, or unreachable states. The proposed idea is illustrated by an example of a real-life production process.

17

Elaboration of financial fraud ontology

Hussaini Adamu, Guessoum Zahia, Mercier-Laurent Eunika

Annals of Computer Science and Information Systems

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2022

|

Vol. 32

277--285

EN

Financial Frauds have dynamically changed, the fraudsters are becoming more sophisticated.There has been an estimated global loss of 5.127 trillion each year due to various forms of financial frauds. Industries like banking, insurance, e-commerce and telecommunication are the main victims of financial frauds. Several techniques have been proposed and applied to understand and detect financial frauds. In this paper we propose an ontology to describe financial frauds and related knowledge. The aim of this ontology is to provide a semantic framework for the detection of financial frauds. Theoretical ontology has been elaborated exploring various sources of information. After describing the research objectives, related works and research methodology, this paper presents details of theoretical ontology. It is followed by its validation using real data sets. Discussion of the obtained results gives some perspectives for the future work.

18

High performance thin layer chromatography (HPTLC) method development and validation for determination of doxycycline hyclate in capsule and tablet formulations

Kumssa Lensi, Layloff Thomas, Hymete Ariaya, Ashenef Ayenew

Acta Chromatographica

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2022

|

Vol. 34, no. 3

287--295

EN

According to World Health Organization (WHO) 10% of the medicines in the Low and Middle Income Countries (LMICs) are of poor quality posing a major public health threat. One way to circumvent such problem is the development and deployment of rapid, economical and efficient analytical methods. Hence this research aims to develop a High-Performance Thin Layer Chromatography (HPTLC) method for the determination of doxycycline hyclate. A rapid and simple HPTLC method with densitometry detection at 360 nm to determine doxycycline hyclate in capsules and tablet formulations was developed and validated. HPTLC was performed on glass plates coated with C18 reverse phase silica gel 60 F₂₅₄ and pretreated with 0.27 M ethylenediaminetetraaceticacid (EDTA) solution. The mobile phase was dichloromethane: methanol: acetonitrile: 1% aqueous ammonia in the ratio of 10:22:53:15 (v/v). The linearity range lies between 200 and 1,000 ng/spot with correlation coefficient of 0.997. The Rf value is 0.5 ± 0.02%. Recoveries were in the range of 94.50–100.5%. Limit of detection and limit of quantitation values for doxycycline hyclate were 40 and 160 ng/spot respectively. The developer method was validated as per ICH guidelines. Thus, it was found to be accurate, precise, specific and robust. In forced degradation study, doxycycline hyclate was found to degrade in acidic and alkaline media, and through oxidative stress. The drug was found to be relatively stable to heat and photo degradation. The method was successfully applied for the routine quantitative analysis of dosage forms containing doxycycline hyclate. The developed method offered comparable results (as confirmed by F-test) with that of the HPLC pharmacopoeial (BP) analysis method.

19

Development and validation of UPLC-MS/MS method for in vitro quantitative analysis of pyrazinamide in lipid core-shell nanoarchitectonics for improved metabolic stability

Thalla Maharshi, Jala Aishwarya, Borkar Roshan M., Banerjee Subham

Acta Chromatographica

|

2022

|

Vol. 34, no. 3

237--245

EN

Pyrazinamide (PZA), a medication for tuberculosis, has high aqueous solubility and low permeability, undergoes extensive liver metabolism, and exhibits liver toxicity through its metabolites. To avoid this, PZA in lipid core-shell nanoarchitectonics has been formulated to target lymphatic uptake and provide metabolic stability to the incorporated drug. The UPLC-MS/MS method for reliable in vitro quantitative analysis of pyrazinamide (PZA) in lipid core-shell nanoarchitectonics as per ICH guidance was developed and validated using the HILIC column. The developed UPLC-MS/MS method is a simple, precise, accurate, reproducible, and sensitive method for the estimation of PZA in PZA-loaded lipid core-shell nanoarchitectonics for the in vitro determination of % entrapment efficiency, % loading of pyrazinamide, and microsomal stability of lipid core-shell nanoarchitectonics in human liver micro- somes. The % entrapment efficiency was found to be 42.72% (±12.60). Lipid nanoarchitectonics was found to be stable in human liver microsomes, where %QH was found to be 6.20%, that is, low clearance. Thus, this formulation is suitable for preventing PZA-mediated extensive liver metabolism. These findings are relevant for the development of other lipid-mediated, suitable, stable nano- formulations containing PZA through various in vitro methods.

20

Validation of aperiodic and oscillatory stability calculations in a practical power systems

Razzhivin Igor, Suvorov Aleksey, Andreev Mikhail, Gusev Alexander

Przegląd Elektrotechniczny

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2021

|

R. 97, nr 6

136--139

EN

The stability of electric power systems is one of its most important properties. This article discusses small-disturbance rotor angle stability: aperiodic and oscillatory. The authors consider, typically for stability analysis, the numerical integration methods by modeling in known numerous digital software simulation tools and propose a method for validating of simulation results by benchmark tool instead of field data. The feasibility of the proposed approach is clearly illustrated by the given fragments of the corresponding experimental studies.

PL

Stabilność systemów elektroenergetycznych jest jedną z jego najważniejszych właściwości. W artykule omówiono stabilność kątową wirnika o małych zakłóceniach: aperiodyczną i oscylacyjną. Autorzy rozważają, typowo dla analizy stabilności, metody integracji numerycznej poprzez modelowanie w znanych licznych narzędziach do symulacji oprogramowania cyfrowego i proponują metodę walidacji wyników symulacji za pomocą narzędzia wzorcowego zamiast danych terenowych. Wykonalność proponowanego podejścia wyraźnie ilustrują podane fragmenty odpowiednich badań eksperymentaln.