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pH-dependent composite coatings for controlled drug delivery system — Review

Pawłowski Łukasz, Bartmański Michał, Zieliński Andrzej

Inżynieria Materiałowa

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2019

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Vol. 40, nr 3

62--67

EN

Nowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loosening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial cover in the tissues surrounding the implant, research is performed on materials that are carriers of drugs, which release active substances only in the case of the pH change in the system during inflammation. In consequence, biomaterials ensure antibacterial protection for a long time, not only in short post-operative period. An example of such materials are biopolymers. Biopolymers sensitive to change in pH value of the environment of live tissue that surround the implants can be used as an independent implants or as the coatings on the implants. In this case in the polymer`s matrix is dispersed often used drugs such as doxorubicin, gentamicin, vancomycin and cefuroxime. Drugs are released from this biomaterial according to three main mechanisms: diffusion, swelling and material degradation. This review paper presents the mechanism of bacterial interaction with implant surface and biofilm formation, and mechanism of drugs release from the biological active substance. Therefore, the natural and synthetic polymer materials sensitive to the lower value of pH such as chitosan, Eudragit E 100, Poly (L-histidine) and Poly (4-vinyl pyridine) are described.

PL

W artykule omówiono problem zakażeń bakteryjnych związanych z wszczepieniem biomateriału do organizmu człowieka oraz sposoby ograniczania rozwoju tych zakażeń za pomocą kontrolowanych systemów dostarczania leków, bazując na obszernym przeglądzie najnowszej literatury naukowej.

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Symulacje numeryczne procesu desorpcji i dyfuzji leku w materiale z nanowłókien

Nakielski P.

Modelowanie Inżynierskie

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2013

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T. 17, nr 48

99--111

PL

W pracy przedstawiono symulacje metodą elementów skończonych procesu desorpcji leku z powierzchni nanowłókien oraz dyfuzji wewnątrz porowatego materiału w zależności od wzajemnej konfiguracji włókien. Zbadano uwalnianie leku w różnych typach ułożenia włókien w materiale od idealnie ukierunkowanych po włókna ułożone nieregularnie. Dodatkowo przeanalizowano wpływ lokalnego zagęszczenia włókien i porowatości materiału na proces dyfuzji w macie. Przedstawiony model porównano z wynikiem eksperymentalnym uwalniania Rodaminy B z elektroprzędzonych nanowłókien oraz rozwiązaniem analitycznym dyfuzji z płaskiej płyty z homogenicznie rozmieszczonym lekiem. Celem przeprowadzonych obliczeń jest znalezienie kluczowych parametrów materiału, stosowanego jako system uwalniania leków w zapobieganiu neurodegeneracji po operacjach neurochirurgicznych.

EN

In the paper the finite element simulations of desorption of drug from the surface of the nanofibers and diffusion inside the porous material, depending on the configuration of the fibers are presented. Drug release was examined in various types of the fibers arrangement from perfectly oriented to irregularly arranged. In addition, the impact of the local compaction of fibers and porosity of mats on the process of diffusion in the material was analyzed. The presented model was compared with the experimental result of the release of Rhodamine B from electrospun nanofibers and with the analytical solution of diffusion from a flat plate with a homogeneously distributed drug. The aim of the work is to find the key parameters of the material, used as a drug delivery system for the prevention of neurodegeneration after neurosurgical procedures.

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Perspektywy zastosowania nowych nanomateriałów węglowych w kontrolowanym uwalnianiu leków

Pacholczyk A.M., Terzyk A.P., Wiśniewski M.

Wiadomości Chemiczne

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2010

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[Z] 64, 1-2

23-44

EN

Drug delivery systems have many advantages compared to typical therapy and due to progress in nanotechnology still new systems are proposed for this purpose. The major advantages are for example: applicability of drugs poorly soluble in water, controlled transport, combined therapy where one or more drugs can be simultaneously applied and generally, better efficiency. In this review we analyze a group of .model. drugs applied for testing of those systems [5] and pay also attention to other important drugs [7, 8, 13, 14]. The applicability of older (for example polymers [2]) as well as new nanomaterials (silicas [6, 7, 9, 10, 12.17], gels [6, 18]) in drug delivery systems is discussed. Special attention is paid to new carbon materials i.e. carbon nanotubes and carbon nanohorns (Figs. 1.3) [1, 2, 20.24, 28.41]. We report recent advances in this field showing the potential applicability of those materials in drug delivery systems. Special attention is paid to the systems where anti-cancer drug cisplatin was covalently bound to the edges or incorporated inside single-wall carbon nanohorns. We also discuss the applicability of buckysomes, especially in delivery of hydrophobic anti-cancer drugs. Finally reports about toxicity of new forms of carbon are discussed and it is shown that many of them lead to contradictory conclusions [22, 42.55].

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Gentamycyny z nowego kopolimeru blokowego - badania in vitro

Prowans P.

Inżynieria Biomateriałów

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2004

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R. 7, nr 34

38-40