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Association between the N-acetylation genetic polymorphism and aspirin-induced urticartia

Porębski G., Obtulowicz K., Piwowar M., Roterman-Konieczna I.

Bio-Algorithms and Med-Systems

2008

Vol. 4, no. 8

19--23

N-acetylation represents one of the key pharmacogenetic traits in metabolism of xenobiotics, including drugs. Dominance of ‘slow-acetylators’ has been demonstrated in atopic patients, contact allergy and has been investigated in patients with sulfonamide hypersensitivity. The aim of this survey was to assess genotype of N-acetyltransferase2 (NAT2) polymorphism in patients with aspirin-induced urticaria (AIU). To the study we included 24 consecutive patients with medical history of urticaria induced by aspirin and 123 healthy controls. In the patients’ group oral provocation tests (OPT) up to 565mg cumulative dose of acetylsalicylic acid were performed. The NAT2 alleles (*4-wilde type, *5, *6 and *7) were determined by polymerase chain reaction-restriction fragment length polymorphism method with DNA extracted from peripherial blood. It was observed 53.7% of slow acetylators in the control group, and respectively 66.7%, 83.3% and 100% in the patients with AIU, in patients with positive OPT and in patients with positive reaction in OPT assessed as severe. Statistical significance association between NAT2*5/NAT2*6 genotype and aspirin-induced urticaria was revealed. The linkage of AIU and slow acetylation (NAT2*5/NAT2*6) seems to be highly probable in the patients with medical history of skin hypersensitivity to aspirin confirmed by positive oral provocation test.

Decision support system for differential diagnosis of local edema and urticaria with allergic background

Porębski G., Walecki P., Wardach E., Obtułowicz K.

Bio-Algorithms and Med-Systems

2006

Vol. 2, no. 4

83--90

This paper presents a web-based decision support system (DSS) for differential diagnosis of local edema and urticaria with allergic background. This decision support system is a simply Clinical Practice Guidelines Online (CPGO) which refers to the Evidence Based Medicine (EBM) methodology. The system is integrated with Polish Association for Helping People with Angioedema website in the e-learning

W pracy zaprezentowano system wspomagania decyzji w diagnostyce różnicowej obrzęku miejscowego i obrzęko-pokrzywki o podłożu alergicznym, który dostępny jest za pośrednictwem sieci internetowej. Przedstawiany projekt jest przykładem prostego systemu wytycznych praktyki klinicznej, które oparte są o metodologię EBM. System jest zintegrowany z materiałami edukacyjnymi udostępnionymi na stronie Polskiego Stowarzyszenia Pomocy Chorym z Obrzękiem Naczynioworuchowym.