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Ultrasound investigations of the effect of 4-hydroxycoumarin and umbelliferone on lipid bilayers

Wójtowicz K.

Molecular and Quantum Acoustics

2007

Vol. 28

285-292

Ultrasound absorption technique was applied to compare the influence of two coumarines: 4-hydroxycoumarin and umbe1liferone (7-hydroxycoumarin) on the phase transition of lipid membranes. There was examined the effect of these coumarines on lipid membranes obtained on the basis of three lecithins differing from each other by the length of acyl chain: dimirystoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine (DPPC) and distearoylphosphatidylcholine (DSPC). 4-hydroxycoumarin was found to change both phase transition temperature of this transition, and cooperativity more than umbelliferone in the case of all the three lecithins.

The Effect of Cholesterol and 7-Dechydrocholesterol on Lipid Bilayers. Ultrasound Study

Wójtowicz K., Gawda H.

Molecular and Quantum Acoustics

2004

Vol. 25

243-248

In the study effect on phosphocholine bilayers of cholesterol additive and of 7-DHC additive was compared depending on the lenght of phosphocholine acyl chain. Ultrasound absorption measurements were the basis of invastigations. They have shown that structurally similar cholesterol and 7-DHC molecue, by being more flat and elastic than a cholesterol molecule, more strongly binds with lipid molecules.