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System-level modeling of a Lab-On-Chip for micropollutants detection

Guiton S, Rezgui A, Madec M., Lallement C., Rufi F, Haiech J.

International Journal of Microelectronics and Computer Science

2014

Vol. 5, nr 3

116--125

The issue addressed by this paper is system-level modeling of Lab-On-Chip (LOC) level. These microsystems integrate within a single chip many functions from several domains such as electronics, thermic, biochemistry or microﬂuidics. The modeling of these systems in a single environment and the interface between different domains is very challenging. In this paper, we propose some methods to model the entire system in VHDL-AMS. The models are developed and assembled from elementary building blocks, with a validation through experiments or numerical simulation on a reference tool, toward the complete LOC. For each domain, the modeling methodology is described. The principle is applied to a specific use case: a LOC designed for the detection of micro-pollutants in drinking water. It is based on the ELISA test leading to a pH-shift which is in turn detected by an Ion-Sensitive Field Effect Transistor (ISFET). In the last part of the paper, the ﬁrst results obtained with the complete zero-order model of the LOC are described. Of course, this model has to be improved in order to be faithful to the actual LOC but it will undoubtedly be a major asset for the optimization and reliability improvement of the LOC.

Modelowanie hydrodynamiki w układach mikroprzepływowych

Ilnicki F., Wawro B., Pijanowska B., Torbicz W.

Przegląd Elektrotechniczny

2010

R. 86, nr 10

27-29

Stosowanie narzędzi inżynierskich służących do modelowania procesów fizycznych i chemicznych daje możliwość znacznej obniżki niezbędnych kosztów oraz czasu, związanych z projektowaniem i wdrażaniem nowych technologii oraz urządzeń. W artykule omówiono zastosowanie modelowania FEM do optymalizacji i analizy hydrodynamiki w układach mikroprzepływowych typu lab-on-a-chip. Przedstawiono przykładowe symulacje komputerowe hydrodynamiki w mikroreaktorze przeznaczonym do hodowli komórkowych oraz ogniskowania hydrodynamicznego w mikrocytometrze przepływowym.

Dynamic progress in computer science results in development and optimization of engineering tools for designing and modeling of physical and chemical processes and phenomena. They reduce costs and time devoted to design and implementation of new technologies and devices. For these purposes, computational numeric methods such as: finite element, volume and finite difference method (FEM, FVM and FDM, respectively) are the most frequently used. In this paper, application of the FEM based modeling for optimization and analysis of hydrodynamics in lab-on-a-chip type microfluidic systems are presented. Exemplary results on computer simulations of hydrodynamics in flow-through microreactors for cell culturing and hydrodynamic focusing in flow microcytometer are discussed. Computer simulations were performed with a simulation software package COMSOL 3.5.