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1 2005

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Studies on the Distribution of Mefenamic Acid in Two-Phase Systems: Aromatic Solvent-Water

Zapała L., Kalembkiewicz J., Szlachta J.

Polish Journal of Chemistry

2005

Vol. 79 / nr 7

1235-1244

The detailed description of equilibria of mefenamic acid in the aqueous solutions and in the two-phase systems: aromatic solvent - water was made. Isoelectric point, pHI, dissociation constants of the protonated form,Ka1, and the neutral form,Ka2, in the aqueous solutions were determined. On the basis of the spectrophotometric investigations the values of the distribution ratio, D, of mefenamic acid were obtained. Employing the results of the potentiometric titration in the two-phase systems, organic solvent - water, and using models of singular and multistep equilibrium the values of the partition constants, KD, and dimerization constants, Kd, were calculated. The significant influence of the polarity of the applied organic solvents and of pH of the aqueous phase on the percentage of the particular forms of mefenamic acid in the two-phase systems were proved. Key words: mefenamic acid, liquid-liquid distribution, two-phase systems equilibria