Wyniki wyszukiwania - BazTech

1

Aminy biogenne w aspekcie ich roli w organizmach żywych

Jastrząb R., Tylkowski B.

Wiadomości Chemiczne

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2016

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[Z] 70, 1-2

57--79

EN

Although polyamines (PA) belong to relatively simple aliphatic substances, their role in life processes of animals and plants is of key importance [1–5]. The group of the most important amines, called biogenic ones includes: Spermine (Spm): H2N(CH2)3NH(CH2)4NH(CH2)3NH2 Spermidine (Spd): H2N(CH2)3NH(CH2)4NH2 Putrescine (Put): H2N(CH2)4NH2. Of secondary importance are homologues of biogenic amines, occurring in lower contents in living organisms [2, 6–8]: 1,3-diaminopropan: H2N(CH2)3NH2 Cadaverine: H2N(CH2)5NH2 Homospermidine: H2N(CH2)4NH(CH2)4NH2 Norspermine (3,3,3-tet): H2N(CH2)3NH(CH2)3NH(CH2)3NH2 Thermospermine: H2N(CH2)3NH(CH2)4NH(CH2)4NH2 Caldopentamine: H2N(CH2)3NH(CH2)3NH(CH2)3NH(CH2)3NH2. The first polyamine discovered in a living organism was tetramine, a spermine crystallised out of sperm in 1678 by Van Leewenkeuk [9]. Putrescine was discovered in the end of the 19th century in microbes and then triamine: spermidine was discovered in the beginning of the 20th century [2]. Later studies have shown that in animal cells spermidine and spermine occur at elevated levels, while in prokaryotes spermidine and putrescine contents are dominant. Putrescine, spermidine, 1,3-diaminopropan, homospermidine, norspermidine, and norspermine have been found in many gramnegative bacteria and algae [7, 10, 11]. Total concentration of PA in living organisms is on the order of millimols, however, the concentration of free polyamines is much lower. A low level of free amines follows from the fact that they are involved in noncovalent interactions with biomolecules occurring in living organisms such as nucleic acids, proteins, or phospholipids. High concentrations of non-bonded polyamines have been detected first of all in young molecules in the process of growth, in particular in rapidly proliferating cancer cells [6, 12]. Elevated levels of free polyamines have been observed, e.g. in breast, colon, lung, prostate, and skin tumours, accompanied by changed levels of enzymes responsible for biosynthesis and catabolism of polyamines. Because of the increased level of free polyamines and a tendency of their interaction with nucleic acids and other bioligands, these compounds have become objects of intense study [1, 13–19]. There is no doubt that the regulation of biosynthesis of polyamines and catabolism is one of the most important pathways in the search strategy for chemoprevention and chemotherapeutic drugs [14, 15, 20–36]. The present state of knowledge of these processes, their significance in biological systems, and their application in medicine are presented in subsequent sections of this chapter.

2

Logistyka w badaniach stanu wiedzy kobiet z zakresu zagrożenia nowotworami

Sirak J.

Logistyka

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2014

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nr 4

PL

W niniejszym artykule przedstawiono wyniki badań wstępnych, celem których była ocena poziomu wiedzy kobiet na temat nowotworów szyjki i trzonu macicy. Badania te, wykazały, iż wiedza kobiet w tym zakresie jest niezadowalająca. Aby poprawić stan wiedzy kobiet na temat nowotworów należy zwiększyć efektywność przepływu informacji o uwarunkowaniach nowotworów, za pomocą akcji profilaktycznych oraz edukacji na różnych poziomach kształcenia.

EN

The article presents the results of preliminary studies, the aim of which was to evaluate the level of women’s knowledge about cervical cancer and endometrial cancer. These studies have shown that women's knowledge in this range is unsatisfactory. To improve the state of women's knowledge about cancer the logistics flow of information on the determinants of cancers should be increased by conduction of preventive actions and informative processes at different levels of education.

3

Electroporation of transplantable tumors for the enhanced accumulation of photosensitizers

Tamosiunas M., Bagdonas S., Didziapetriene J., Rotomskis R.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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2006

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Vol. 12, nr 1

57-59

EN

The aim of this study was to verify whether electroporation could affect the accumulation of the hydrophilic photosensitizers: aluminum phthalocyanine tetrasulphonate (AIPcS4) and chlorin e6 (Ce6) in tumor tissue. The experiment was performed in vitro using hybrid mice (C57B1/CBA) bearing the tumors transplanted in the right haunch. The fluorescence intensity of photosensitizers was measured from the surface of the skin covering tumors at different time intervals after the ordinary (passive) and electrically enhanced delivery. The fluorescence spectroscopy results imply that electrical field affected the tumors in a way, which led to the higher accumulation of both photosensitizers (AIPcS4 and e6) in the periphery and the superficial layers of tumors.

PL

Celem badań była ocena wpływu elektroporacji na gromadzenie się w tkankach nowotworowych fotouczulaczy hudrofilowych, tj.:tetrasulfonian glinku ftalecyjaniny (AIPcS4), chlorin e6 (Ce6). W doświadczeniu in vitro użyto hybryd mysz (C57B1/CBA) po wcześniejszym przeszczepieniu komórek nowotworowych. Zmierzono natężenie fluorescencji fotouczulacza z powierzchni skóry pokrywającej zmiany nowotworowe. Badania przeprowadzono w różnych odstępach czasu, po pasywnych i elektrycznie wspomaganych procesach. Wyniki spektroskopii fluorescencyjnej sugerują, iż pole elektryczne wpływa na nowotwory, prowadząc do intensywniejszej akumulacji obu fotouczulaczy (AIPcS4 i e6) w obwodowej oraz powierzchniowej warstwie zmian patologicznych.

4

Photodynamic therapy: a new concept and a clinical reality for medicine

Ion R.-M.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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2004

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Vol. 10, nr 1-2

11-13

5

Ocena przydatności kwasu aminolewulinowego (ALA) podawanego drogą wziewną w diagnostyce fotodynamicznej nowotworów oskrzeli - wyniki wstępne

Piotrowski W., Marczak J., Antczak A., Górski P.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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2003

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Vol. 9, nr 3-4

167-168