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Positron emission tomography (PET) in oncology: current applications and future perspectives

Trofimiuk-Müldner M., Hubalewska-Dydejczyk A.

Bio-Algorithms and Med-Systems

2014

Vol. 10, no. 1

47--52

Positron emission tomography (PET), particularly dual-modality imaging systems (PET/CT or PET/MRI), has evolved from being a research tool into a valuable clinical modality, particularly in the field of oncology. Currently, most of the PET/CT examinations are done with FDG when assessing glucose metabolism in tumors. FDG PET or PET/CT has been proven to be a valuable method in staging, restaging, therapy response assessment, early recurrence detection, and in unknown primary focus localization. However, PET/CT has its limitations, leading to both false-positive and false-negative results. Proper design and/or choice of an alternative tracer may overcome those problems as well as give better insight into tumor biology and result in more thorough assessment and effective therapeutic approach in patients with cancer.

Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars

Sugiyama M., Yamashita M., Yu G., Fujie M., Ogawa K., Ozaki N., Aoki T., Mizuno S., Okada S., Tachi K., Aoshima K., Sankar U. R., Kumar B. S., Takehara Y., Sakahara H.

Journal of Automation Mobile Robotics and Intelligent Systems

2009

Vol. 3, No. 4

191-194

MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.