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2 Polish Journal of Chemistry

2 Dzierzbicka K.

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Synthesis of Conjugates of Amino-Combretastatin with Tuftsin Derivatives as Potential Anticancer Agents

Dzierzbicka K.

Polish Journal of Chemistry

2009

Vol. 83, nr 1

81-85

Novel 3'-N-(tuftsin or retro-tuftsin)-amino-combretastatin conjugates have been synthesized as potential anticancer compounds. We hope that the conjugation of immunomodulators like tuftsin derivatives with amino-combretastatin A-4 would improve the therapeutical properties of combretastatin A-4.

Synthesis of Conjugates of Muramyl Dipeptide and nor-Muramyl Dipeptide with Retro-Tuftsin (Arg-Pro-Lys-ThrOMe) as Potential Immunostimulants

Dzierzbicka K.

Polish Journal of Chemistry

2004

Vol. 78 / nr 3

409-416

The synthesis of retro-tuftsin analogue of sequence Arg-Pro-Lys-ThrOMe (Scheme 1) and it's conjugates containing MDP (muramyl dipeptide) or nor-MDP (nor-muramyl dipeptide) (Scheme 2) are described.