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Trabecular bone remodelling in the femur of C57BL/6J mice treated with diclofenac in combination with treadmill exercise

Lehmann Tomasz P., Wojtków Magdalena, Pruszyńska-Oszmałek Ewa, Kołodziejski Paweł, Pezowicz Celina, Trzaskowska Aleksandra, Mielcarek Sławomir, Szybowicz Mirosław, Nowicka Ariadna B., Nowicki Marek, Misterska Ewa, Iwańczyk-Skalska Ewa, Jagodziński Paweł, Głowacki Maciej

Acta of Bioengineering and Biomechanics

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2021

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Vol. 23, no. 3

3--11

EN

Purpose: Analgesic treatment with diclofenac deteriorates bone structure and decreases biomechanical properties. This bone loss has been though to be reversed by training. The impact of exercise on bone treated with diclofenac (DF) has reminded elusive. In the present study, we assayed the combined impact of exercises and DF on mouse femur. Methods: The femur samples we obtained from 30 days treated C57BL/6J female mice. The training group ran on a horizontal treadmill at 12 m/min by 30 min a day (5% grade/slope). The group of ten mice treated with DF received the drug subcutaneously every day (5 mg/kg of body weight/day). The combined group ran on the treadmill and obtained DF. After 30 days, we sacrificed mice and studied their femurs using microcomputed tomography (µCT), dynamic mechanical analysis (DMA) and nanoindentation. Results: We observed that treadmill running and DF decreased trabecular bone volume and mineral density. Combined effect of training and DF was not additive. A significant interaction of both parameters suggested protective effect of training on bone loss provoked by DF. The femur cortical bone shell remained untouched by the training and treatment. The training and the DF treatment did not alter the storage modulus E’ significantly. The unchanged storage modulus would be suggesting on the unaltered bone strength. Conclusions: We concluded that even relatively short time of training with concomitant DF treatment could be protective on trabecular bone. Although viscoelastic properties of the entire femur were not modulated, femur trabecular tissue was thinned by treatment with DF and protected by training.

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Modeling and experimental validation of walking processes

Nigmatullin Raoul R., Morozov Arsenii L., Awrejcewicz Jan, Ludwicki Michal

Biocybernetics and Biomedical Engineering

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2020

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Vol. 40, no. 1

200--210

EN

The so-called intermediate model (IM) was applied in the paper to quantitatively describe complex trajectories. Using this model it was possible to find the proper fitting function for describing random trajectories that were recorded during the walking process performed by a volunteer. Experimental data were acquired using a three-dimensional Motion Capture system during normal gait of a healthy person on an automatic treadmill. The major aim of this research was to find if the IM is applicable to fit typical biomechanical measurement data. Motion Capture data collection is very time-consuming and requires a lot of memory, so storing movement trajectories in a parametric form helps to increase the data processing efficiency and mathematical analysis. As a result of the original treatment procedure described in this paper, we obtained a very accurate fit of the measured data. The results of this research can be used to model the movement of mechanical devices and for diagnostic purposes.

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Analiza częstości akcji serca ratownika górniczego – część 2

Grodzicka A., Szlązak J., Buchwald P., Dopierała J.

Wiadomości Górnicze

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2017

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R. 68, nr 11

568--573

PL

W drugiej części cyklu artykułów przedstawiono wyniki badań przeprowadzonych na terenie OSRG w Bytomiu, w komorze ćwiczeń, podczas wykonywania ćwiczeń na bieżni. W badaniu wzięło udział 125 ratowników, których podzielono według wieku na trzy grupy, tj. do lat 30, od 31 do 40 oraz powyżej 40 lat, uwzględniając kolejność wykonywanych ćwiczeń.

EN

The second part of the article series presents the results of research inducted on the site of Regional Mines Rescue Station /RMRS/ in Bytom, in the training chamber, while performing exercises on the treadmill. The survey involved 125 rescuers, who were divided according to their age into three groups, i. e. up to the age of 30, from 31 to 40 and over 40, king into account the sequence of exercises being performed.

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Evaluation of the impact of exercise of gait on a treadmill on balance of people who suffered from cerebral stroke

Drużbicki M., Przysada G., Guzik A., Kwolek A., Brzozowska-Magoń A., Sobolewski M.

Acta of Bioengineering and Biomechanics

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2016

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Vol. 18, no. 4

41--48

EN

Purpose: The aim of the study is to define the impact of exercise on a treadmill on static balance and stability of posture in a group of patients after cerebral stroke rehabilitated in a late period, with an application of a treadmill with the function of visual biofeedback. Methods: The examination was carried out in a group of 46 people in a late period after ischemic cerebral stroke. The patients examined were randomly put to a group with intervention (n = 23), in which a rehabilitation programme with an application of a treadmill with the visual feedback function was realized and to a control group (n = 23). They evaluated balance in standing on both feet by means of a force plate, symmetry of load of lower limbs and dynamic balance in Up & Go test. Results: A statistically significant change of stabilometric parameters was observed only in the area of postural sways of the centre of pressure (COP). A significant improvement of the symmetry of load of lower limbs in standing ( p = 0.0266) was diagnosed in the examined group after the end of the programme. After the end of the programme no significant difference between the group with intervention and the control group as for a change of balance of the examined patients was found. Conclusions: In the examined group in the chronic period after cs no significant improvement of stabilometrically evaluated balance was obtained, but improvement of the symmetry of load of lower limbs as well as improvement of dynamic balance were observed.

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Study on ballistocardiogram acquisition in a moving wheelchair with embedded sensors

Pinheiro E., Postolache O., Girao P.

Metrology and Measurement Systems

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2012

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Vol. 19, nr 4

739-750

EN

Embedding cardiac system sensing devices in wheelchairs is both necessary and attractive. Elders, diabetics, or stroke victims are a substantial group needing permanent cardiac monitoring, without restriction of their already limited mobility. A set of sensing devices was embedded in a wheelchair to monitor the user without his awareness and intervention. A dual-wavelength reflection photoplethysmogram (PPG), and a ballistocardiogram (BCG) based on MEMS accelerometers and on electromechanical film sensors are output by the hardware. Tests were conduced on twenty one subjects, for an immobility scenario. Additional recordings were made for helped propulsion over a tiled floor course, with good results in keeping track of acceleration BCG and PPG. A treadmill was also used for tests, providing a smooth floor and constant speed and inclination. The PPG and acceleration BCG could be continuously monitored in all the tests. The developed system proves to be a good solution to monitor cardiac activity of wheelchair users even during motion.

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A robotic stepper device concept for locomotion rehabilitation

Bejczy A. K.

Archives of Control Sciences

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2002

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Vol. 12, no. 1/2

89-102

EN

A novel strategy for rehabilitation of locomotion impaired subjects uses a Body Weight Support Technique (BWST) on a treadmill which involves three to four therapists to carry out the required patient training exercises on the readmill. This paper briefly describes (i) the essence of the novel rehabilitation strategy, including its medical background, (ii) the technical approach to the design and development of a robotic device aimed to reduce the manual involvement of at least two therapists in the locomotion training exercises on a treadmill, and (iii) the main conceptual design features of a possible robotic device.