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2 Biocybernetics and Biomedical Engineering

2 2004

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Polypropylene surface modified hollow fibers for immunoisolation of cells

Granicka L. H., Chwojnowski A., Kawiak J.

Biocybernetics and Biomedical Engineering

2004

Vol. 24, no. 2

59-67

Membranes preventing the tissue overgrowth as well as toxic influence of the environment on cells encapsulated within them were elaborated. The permiselective polypropylene hollow fibers were modified using different methods of silanization, and the effect of silanization on the membrane transport properties as well as on the tissue overgrowth was assessed, in the light of their perspective application in encapsulation of the cells. The membrane's pressure silanization has been found to result in obtaining membranes allowing to decrease and/ or delimit the diffusive transport through the membrane of large solutes without a simultaneous transport change for small solutes. The applied different types of membrane's silanization allowed to avoid a massive tissue overgrowth during the implantation. The membranes have been found to comply with the requirements for membranes applied in immunoisolation.

Evaluation of the new polyurethanes capillary membrane for cell immunoisolation. Results from in vitro studies

Resiak I., Wojciechowski C.

Biocybernetics and Biomedical Engineering

2004

Vol. 24, no. 2

69-79

Highly biocompatible and mechanically resistant semipermeable membranes are required for macroencapsulation of cells or tissues. For this purpose two series of aromatic as well as aliphatic polyurethanes were elaborated for the production of hollow fibre membranes by the phase inversion method and the wet spinning technique. The influence of the polyurethane structure, i.e. type of the hard segments and content of the soft segments on the membrane morphology and its transport properties were investigated.