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2 2023

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Geometrical Accuracy and Strength of Micro-Needles Made of Polylactide by Fused Filament Fabrication Method

Wichniarek Radosław, Kuczko Wiesław, Tomczak Dorota, Nowicka Ariadna B., Wojtyłko Monika, Froelich Anna, Osmałek Tomasz

Advances in Science and Technology. Research Journal

2023

Vol. 17, no 6

116--126

Additive manufacturing is a technology that can be successfully used in pharmacy and medicine. One of the examples of products that can be additively manufactured are microneedle systems. The specificity of these products, which are used for transdermal drug delivery, makes additive manufacturing a perfect choice for related research. However, the dimensions of microneedles usually do not exceed 2 mm, which means that manufacturing them using the most widely available additive manufacturing method, Fused Deposition Modelling (FDM), is problematic. In this study, the authors decided to investigate the possibilities of manufacturing microneedle systems using the FDM method in such a way as to minimize or exclude the need for post-processing. Five types of microneedle geometries were tested in four sizes, examining how changing the values of FDM process parameters would affect the accuracy of reproducing the digital geometry of the microneedles. From the point of view of the application of microneedle systems, it is not only necessary to obtain the designed shape of the microneedles, but also to maintain their appropriate strength. The study presents the results of the bending and compression strength of microneedles made of polylactic acid.

Evaluation of design and insertion analysis of a conical shaped polymeric based microneedle for transdermal drug delivery applications

Gera Aswani Kumar, Burra Rajesh Kumar

Acta Innovations

2023

no. 46

54--65

Transportation of drug through parental routes are conventionally followed through hypodermic injection methods, where hypodermic injections are administered into the human skin for drug release. However, there are some issues observed when these hypodermic needles are being used, there are instances where the needle is being inserted leaves some needle fractures in the skin. To cater to the issue scientific researchers are voraciously working on designing and developing polymeric type of microneedle structures for various medical diagnostic applications for glucose monitoring, drug delivery, and other applications. This article presents the structural design of a conicalshaped polymeric microneedle and the insertion force while being pierced into the skin. Simulations at different insertion angles on microneedle are analyzed by arriving with total needle displacements in the process of insertion. The von mises stress is also analyzed with applied force at different insertion angles resulted in incremental change in stress exerted by the microneedle. The resultant stress is below the yield stress which makes the microneedle pierce into the skin without breakage.