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1 Prace Naukowe Politechniki Warszawskiej. Elektronika

1 2006

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Badania czynnościowe mózgu jako metoda diagnostyki przedoperacyjnej u chorych operowanych z powodu padaczki opornej na leczenie farmakologiczne

Wolak T., Szymańska O., Soluch P., Szeszkowski W., Kurjata R., Orzechowski M., Bogorodzki P., Piątkowska-Janko E., Marchel A., Rysz A., Majkowska-Zwolińska B.

Prace Naukowe Politechniki Warszawskiej. Elektronika

2006

z. 157

19-25

For patients with pharmacoresistant epilepsy only surgieal intervention is an effeetive solution. To prevent unnecessary damage of important regions of the brain, there is a need for mapping of funetional organization of cerebral cortex. In cIinical practiec together with neuropsyehological evaluation an invasive techniques are used: intraoperative cortex mapping using electrieal stimulation and Wada test. In this work, usefulness of fMRI in preoperative planning for those patients was assessed. In cooperation with group of neuropsyehologists five patients were studied. A group of tests was prepared eonsisting of phonetie and semantic fIueney for Broea mapping and a group of motoric tests. All experiments were performed on two seanners for repeatability assessment. For each patient individual maps of active regions were eaculated using SPM2 package and self made tools. For verification of results cIinical evaluation methods were used: Wada test comparison, comparison with intraoperative stimulation and spatial relations between lesions and functional regions. Three of five patients had surgical intervention. None of them presented any degradation in most endangered function - verbal for 2 patients and motoric in one case. All patients will be examined after 6 months. At current stage of study a cIinical protocol is being designed for routine use.