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1 2022

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Analityka antybiotyków β-laktamowych w układzie in silico, in vitro oraz in vivo

Janiszewska Daria, Szultka-Młyńska Małgorzata, Buszewski Bogusław

Wiadomości Chemiczne

2022

[Z] 76, 3-4

109--127

Drug analysis necessitates introducing selective methods of detection and enriching the substances present in biomaterial at low concentration levels (trace analysis). Moreover, there is a continuous demand for increase in the quality of drugs that are being developed, which in turn enforces the development of analytical techniques of increasing sensitivity and accuracy with the applicationof combined separation techniques. Thus the premise of this review is to comparethe in vitro metabolic pathways of antibiotic drugs in model conditions such as in the presence of different microsomal fraction enzymes and with the applicationof electrochemical stimulation of metabolic transformations, as well as to the collected data with the results of in vivo experiments.