Wyniki wyszukiwania - BazTech

Ograniczanie wyników

1 Polish Journal of Chemistry

1 2006

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: telomerase inhibitor

Sortuj według:

Ogranicz wyniki do:

Interactions of the Oxidation Products of Papaverine with Guanine Quadruplexes

Mądry L., Gałęzowska E., Głuszyńska A., Hermann T., Zabel M., Juskowiak B.

Polish Journal of Chemistry

2006

Vol. 80, nr 6

921-929

The interactions of G-quadruplex DNA with two oxidation products of papaverine, 6a,12a-diazadibenzo-[a,g]fluorenylium derivative (1) and 2,3,9,10-tetramethoxy-12- oxo-12H-indolo[2,1-a]isoquinolinium cation (2) were investigated. Effect of the organic modifier (EtOH) and NaCl on the spectral properties and aggregation of free ligands and on the DNA-binding affinity were assessed. Ligand 1 exhibited tendency for aggregation and showed higher binding selectivity for G-quadruplex DNA over double-stranded DNA. Both ligands were capable of interacting with DNA according to three binding modes: (i) electrostatic interactions, (ii) classical intercalation to dsDNA, and (iii) the specific binding to quadruplex DNA. The cytotoxic activity of ligand 2 was generally higher than that for ligand 1, approaching a micromolar concentration level that may suggest its telomerase inhibition activity.