Space in the human body is so limited that nanotechnology and micromachining technology are the important for the development of the internal artificial organs. Based on the nanotechnology, various kinds of artificial organ development have been performed in Tohoku University including artificial myocardium, artificial heart, rotary blood pump, artificial esophagus, and artificial sphincter. Furthermore, automatic control algorithm for the artificial heart and assisted circulation was applied to the invention of the new diagnosis methodology for the baroreflex sensitivity of the patients with hypertension. Successful clinical application of this new invention was performed. The technical application to the large range is expectable in artificial internal-organs development.
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