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1 Journal of Achievements in Materials and Manufacturing Engineering

1 2009

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Spray drying as a method of producing silk sericin powders

Genç G., Narin G., Bayraktar E.

Journal of Achievements in Materials and Manufacturing Engineering

2009

Vol. 37, nr 1

78-86

Purpose: The purpose of paper is to analyse Spray drying as a method of producing silk sericin powders. Design/methodology/approach: Aqueous sericin solutions were used as raw material for the production of dry powders using a lab-scale spray dryer. A linear regression analysis of agglomeration was employed, in addition to experimental designs at two levels with three factors for the analysis of three responses: moisture content, particle type and agglomeration degree. The process factors were the drying air temperature (120şC and 160şC), the feed rate (1.25 × 10-7 and 2.5 × 10-7 mł/s), and the concentration of sericin solutions of 10% and 30% (w/w) fed to the spray dryer. Findings: The three responses were analyzed statistically to determine the effective parameters and it was concluded that moisture content depended on three factors--drying air temperature being the dominant parameter. Particle size and shape depended mainly on feed rate and agglomeration depended on the moisture content of the product. Practical implications: As a result of the growing interest in drug delivery through a pulmonary route for local and systemic effects, the crucial physical characteristics of the spray-dried sericin influencing the dispersion and deposition behaviour including particle size, morphology, moisture content and agglomeration degree were examined for formulation and spray drying variables. Originality/value: The most effective parameters on particle size and morphology were found to be the feed solution concentration and feed rate, while the temperature was an insignificant variable.