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2 International Letters of Chemistry, Physics and Astronomy

2 2014

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Microwave assisted synthesis of 2,5-distyryl-1,3,4-oxadiazole derivatives as anti microbial agents

Namera D. L., Rathod J. B., Maheta R. H., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 10

46--54

A new series of 2,5-distyryl-1,3,4-oxadiazoles derivatives have been synthesized from cinnamic hydrazide on reaction with various cinnamic acid derivatives. The structures of synthesized compounds have been elucidated by spectral studies like IR, 1HNMR, Mass and also Elemental Analysis. Furthermore, all synthesized compounds were screened for in vitro anti microbial activity against the gram positive (Staphylococcus aureus, Pseudomonas aeruginosa) and gram negative (Escherichia coli) bacterial strain. In which some the compounds show potential inhibition against the test organisms.

Convenient synthesis of the 2,5-di-substituted 1,3,4-oxadiazole derivatives under microwave

Namera D. L., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 11, iss. 2

159-166

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method as well as microwave assisted method. The reaction of different substituted cinnamic acid 2a-o with 2-(4-chlorophenyl) acetohydrazide by using phosphoric anhydride as catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole 6a-o. The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the methods, conventional and microwave assisted method, it was proved that the microwave assisted method is convenient for synthesis of this type of 2,5-di-substituted 1,3,4-oxadiazole 6a-o.