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In Vitro Degradation Behaviours of PDO Monofilament and Its Intravascular Stents with Braided Structure

Wang C. E., Zhang P. H.

Autex Research Journal

2016

Vol. 16, no. 2

80--89

Biodegradable intravascular stent has attracted more and more focus in recent years as an effective solution for angiostenosis. Ideal stents were expected to exhibit sufficient radial force to support the vascular wall, while suitable flexibility for the angioplasty. After vascular remodeling, stents should be degraded into small molecular and be eliminated from human body, causing no potential risk. In this paper, poly-p-dioxanone (PDO) monofilament was braided into net structure with four different braiding density, two of which exhibited sufficient radial force larger than 30 kPa, and three of which showed the bending rigidity within 11.7–88.1 N•mm2. The degradation behaviors of monofilaments and stents have been observed for 16 weeks. The findings obtained indicate that degradation first occurred in morphology region, which induced temporary increase of crystallinity, monofilament bending rigidity and stent mechanical properties. During this period, monofilament tends to be hard and brittle and lost its tensile properties. Then the crystalline region was degraded and stent mechanical properties decreased. All the results reveal that the PDO intravascular stents with braided structure were able to afford at least 10 weeks of sufficient support to the vascular wall.

New experimental method to measure the metallic surface area of coronary stents

Károly D., Kovács M., Bognár E.

Selected Engineering Problems

2013

nr 4

115--118

Endovascular stents, such as coronary stents are widely used for the treatment of narrowed or blocked blood vessels. We developed a new experimental method to measure the metallic surface area (MSA) of stents. Our aim was to compare this method with the previously used. According to the results we could make a suggestion to use the new automatic method, because this gives the most and accurate information in the shortest time. The collected experience and results of this study can help physicians to choose an appropriate stent.