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Steering of the process of penetration of chemical substances into biosystem structure

Wójcik M.

Bio-Algorithms and Med-Systems

2011

Vol. 7, no. 1

31--35

The analysis of literature relating questions of processes of penetration through organic membranes such as skin tissue or osseous of the substance both treating as well as harmful require more far investigations, because the present descriptions are insufficient for the new measuring challenges connected with applied contemporarily substances in chemical as well as in mechanical formula. Problem is particularly important in selection of suitable active substances which will accelerate or delay in well-known manner the process of penetration of the proper medicine through organic membranes into biosystem structure subjected for specific medical proceeding for achievement of a declare aim. The penetration through skin tissue of substance of type as the caffeine, theophylline stimulating the central nervous system can be an example of use for deceleration of process of fatigue or the enlargement of durability and the physical resistance as well as the upward movement of vigilance or the man's cognitive abilities. Penetration in osseous tissue of medicine from implant is an other example where it is delivered according to constructed script of medicine interaction. Acquaintance of kinetics of process penetration in both different medical situations will permit to qualify parameters for steering of this phenomenon. It creates then the possibilities for study of new constructions as for instance new generation of sensors applied in surgical navigation in compiled operations of removing the cancer cells of head or the neck for assurance of the local treatment. The review of literature shows, that processes of penetration have been described mainly by the aim of the diffusive mechanism but the closer analysis of question discloses that is sometimes too simplification of the problem. Author proposed the new formulation of question of penetration of medicine from composite implant basing on statistical estimation of the process of transportation captured in suitable variation method in material engineering but he also sees the medical uses of this method. The analysis of control of process is determinant in support about shape of Boltzmann’s entropy here approximated in beta distribution in form as E (Emax - E), where E marks the sum of kinetic energy and potential of penetrating element. Entropy is considered as a Hamiltonian of discussed variation process in the form of following integral [formula]. The suitable variation process in the following form [formula] allows to find and trace the optimum trajectory of transportation of elementary entities into the biological system on basis of an approximation of interaction potentials between transferred medicine and the transferring medium. Euler’s equation which response of the mention variation process in an exemplified formula as [formula] creates these optimum trajectories of the transportation process of penetration. To obtain the progress in closely local method of medical treatment one should be again done in analyze of some investigative procedures what already author have executed in the individual cases. The test of better control of process penetration is the creature of proposed solution and the possibility of steering of this process. The control depends on obtainment of expected progress in medical treatment as a result of the working of well-known parameters in the course of process as well as properties of pharmacological substances having needed potentials activity usually described by pharmacologists, in this case. It seems, that proposed new approach allows on better diagnosis of process penetration because it enriches the hitherto exists formula of diffusive analyses, because the analyzed processes by the aim of mathematical apparatus were not always diffusive. This new proposal is also the challenge for pharmaceutical industry to undertaking the cooperation.