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1 2007

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Bionic design of tube formation in the integrated cellular structure

Tanishita K., Ueda A., Sudo R., Ikeda M., Mitaka T.

Biocybernetics and Biomedical Engineering

2007

Vol. 27, no. 1-2

83-87

The individual cells in the reconstructed cellular structures do not necessarily receive sufficient oxygen and necessary substances supply only by diffusion, and it is necessary to install a blood vessel network formation in the cellular structure. In other words, the vessel network formation is essentially required to achieve cellular function, and to develop a technology of reconstruction of the vessel network installed in the three-dimensional cellular architecture is needed. Here the procedure of the tube formation of blood vessels and bile canaliculi (BC) in vitro is focused on, demonstrating a possibility of tube formation in cellular structures reconstructed in vitro. Particularly, attention to the role of biomechanical processes in the tube formation was paid.