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Optymalizacja projektowania scaffoldu tytanowego przy użyciu wnioskowania rozmytego

Sobieszczyk S.

Engineering of Biomaterials

2010

Vol. 13, no. 99-101

45--47

Opracowano metodę wnioskowania rozmytego do oszacowania geometrii scaffoldu Ti6Al4V, otrzymanego przy użyciu metody metalurgii proszków. Zaproponowana metoda umożliwia oszacowanie i optymalizację architektury scaffoldu poprzez dobór odpowiednich parametrów procesu. Zaprojektowano i przeprowadzono symulację działania sterownika rozmytego (FLC) za pomocą oprogramowania Matlab.

The geometry of Ti6Al4V scaffold, fabricated by powder metallurgy process, has been determined by using fuzzy reasoning approach. A proposed method showed the possibility of estimation and optimization the scaffold’s architecture by choosing an appropriate processing conditions. A fuzzy logic controller (FLC) was utilized using Matlab Software.

Coating of poly(l-lactide-co-glycolide) scaffolds with collagen/glycosaminoglycan matrices and their effects on osteoblast behaviour

Wojak I., Pamuła E., Dobrzyński P., Zimmermann H., Worch H., Scharnweber D., Hintze V.

Engineering of Biomaterials

2009

Vol. 12, no. 86

9-13

Collagen type I and glycosaminoglycans (GAGs) were immobilized on the surfaces of two types of porous biodegradable poly(L-lactide-co-glycolide) (PLGA) scaffolds with pore size in the range of 250-320 µm and 400-600 µm. Two methods of coating were evaluated differing in the way of how the fibrillogenesis solution was introduced into the pores. The distribution of the immunostained collagen in the volume of the scaffolds was analysed with a laser confocal microscope (LSM). The total amount of collagen and GAGs was measured by Sirius Red and Toluidine Blue assays, respectively. The potential of the scaffolds for cell colonization and differentiation was tested in a dynamic cell culture system using human osteosarcoma cells (SAOS-2). The proliferation of SAOS-2 cells was measured by determining the DNA content on days 2 and 7, while differentiation was analyzed by Calcium- and Phosphate-Assays on days 7 and 14. Differentiation of cells was improved by increasing the pore diameter of the scaffolds, and artificial extracellular matrix (aECM) coatings had an additional positive effect for the scaffolds of both pore sizes.