Studies of receptor mediated signaling networks in neuronal cells pro vide a unique opportunity to uncover the basis of many diseases. Receptor signaling c ascades proceed from the cell surface, where extra cellular factors interact with their specific receptors e.g. G-Protein Coupled Receptors ( GPR ). Recent studies have shown that the activation or suppression of GPR 17 in diseased neuronal cells has potential impact in altering the tumor con ditions. We identified many hundred times expressions of GPR 17 in Glioblastoma Multiforme ( GBM ) from the RNA -Seq data. We also observed many other genes having similar expression patt erns with GPR 17, indicating possible connections of this receptor with diverse gen e products. We performed a coarse-grained simulation of ∼ 500 proteins inside a cytoplasm like a box with solvent water molecules. The summarized protein interaction networks r esulted from a coarsegrained simulation and large scale protein-protein docking reveals nov el molecular connections and pathways.
Omówiono podstawowe zagadnienia uogólnionej wieloprotokołowej komutacji etykietowej (GMPLS). Przedstawiono jej architekturę, mechanizmy rutingu oraz sygnalizacji. Opisano także rolę, jaką odgrywa w koncepcji sieci optycznej ASON oraz jej implementacji zaproponowanej przez OIF.
EN
Basic issues regarding generalized multiprotocol label switching (GMPLS), its architecture as well as signaling and routing mechanisms are presented. The role of this concept and related protocols in ASON and its implementation proposed by OIF are presented.
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