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Effects of morphometric and biochemical parameters on collagen and pepsin-solubilized collagen yields of Holothuria tubulosa (Gmelin, 1790) and Holothuria (Roweothuria) poli (Delle Chiaje, 1823)

Künili İbrahim Ender

Oceanological and Hydrobiological Studies

2022

Vol. 51, No. 1

100--114

Due to their unique biochemical composition, sea cucumbers are highly prized marine echinoderm species. One of their most important properties is that they contain a high amount of collagen in their body wall. In this study, the relationship between collagen and pepsin-solubilized collagen yields from Holothuria tubulosa and Holothuria poli and morphometric and biochemical parameters were investigated. Collagen yields were in the range of 10.63–16.04% for H. tubulosa and 7.12–13.10% for H. poli. It was determined that they may be related to length, body wall weight, and biochemical composition at different length frequencies. Moreover, maturity may have a direct effect on the yield, as mature specimens were found to have lower content of collagen, whereas immature small specimens contained a higher percentage of collagen. It was found that with increasing pepsin concentration, the PSC yield increased to 1.83–1.89% in H. tubulosa and H. poli, respectively. It was determined that collagen from smaller individuals, which contained more moisture and ash, was likely more susceptible to pepsin hydrolyzation. This is the first published study demonstrating that collagen yield of sea cucumbers can vary with length, weight, maturity, and biochemical composition, in addition to species-specific differences.

Wydzielanie, właściwości i aktywność przeciwnowotworowa polisacharydów ze strzykwy

Duan Kunfeng

Przemysł Chemiczny

2019

T. 98, nr 2

200--203

Z surowego polisacharydu uzyskanego ze strzykwy (ogórka morskiego) metodą hydrolizy enzymatycznej wydzielono trzy rafinowane polisacharydy, które zastosowano jako inhibitory w leczeniu raka płuc (linia komórkowa A549), raka żołądka (linia komórkowa SGC-7901), raka piersi (linia komórkowa MCF-7) oraz raka trzustki (linia komórkowa PANC-1). Rafinacja poprawiła efekt hamowania wzrostu komórek nowotworowych, zwłaszcza przy zastosowaniu polisacharydów o większym stężeniu. Hamowanie było najskuteczniejsze w przypadku komórek raka piersi MCF-7, a najsłabsze dla komórek raka płuc A549.

Three polysaccharides were prepd. by refining the crude polysaccharide of sea cucumber by enzymatic hydrolysis and studied as cancer inhibitors on human lung cancer cells A549, human gastric carcinoma cells SGC-7901, human breast cancer cells MCF-7 and pancreatic cancer cell PANC-1. The refining resulted in increasing the inhibition effects. They increased also with increasing the polysaccharide concn. The inhibition was strongest in respect to MCF-7 cells and weakest for A549 cells.