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Content available remote Saccadometry and LATER model shed light on brain plasticity in aging
EN
As frequency of falls increases in older adults, understanding how motor training programs counteract motor decline is a challenging issue. This study examined ocular saccades to test the effects of fall prevention (FP) on central motor control of older fallers. Saccades were recorded using a saccadometer in twelve participants aged 64–91 years before and after 2.5-month training in FP. We performed LATER analysis enabling us to examine the changes in motor control. FP decreased saccade latency and increased left-right symmetry of motor responses. LATER analysis showed that FP modulated decisional thresholds extending our knowledge of FP influence on motor control.
2
Content available remote What the future holds for the study of saccades
EN
Here we review the state of the art using saccadic eye movements as windows to the function of the normal brain and of the abnormal brain plagued by disease or trauma. By combining sophisticated behavioral paradigms with rigorous mathematical analysis and the latest imaging techniques one can use saccades as biomarkers of the highest level decision making to the lowest level basic machinery that generates premotor saccade commands. As technology advances saccades will become even more useful as immediate monitors of the state of the brain in disease and trauma and as a way to evaluate therapies.
3
Content available remote Saccadometry and movement inhibition
EN
To reveal some functional constraints of the saccade inhibitory neuronal circuits, we investigated the influence of response monitoring in human. The subjects were instructed to perform a stop signal task in which the probability of stop trial occurrence was manipulated. The purpose of the work was to evaluate the time course necessary to adapt the behavior to changes in the occurrence of stop signal. Our results show that humans are capable to spatially monitor the relative probability event of stopping and to finely and quickly modulate their ability to inhibit a response. These results have important consequence to apprehend pathologies in which, an inaccurate control of inhibitory process results in a loss of fundamental capability of behavioral adaptation.
4
Content available remote Analysing the detail of saccadic reaction time distributions
EN
Measuring saccadic reaction time distributions is an increasingly popular technique, making it possible to obtain a large amount of data non-invasively in a short period of time. Such distributions can often be encapsulated with just two parameters, representing the mean and variance of the rate of rise in the LATER model. For many purposes, both scientific and clinical, this is enough. But for normal as well as pathological subjects, particularly when using more complex tasks, one may often see features that cannot be explained by a simple LATER model. These include early and express saccades, 'late' saccades, and (in tasks such as go/no-go and antisaccades) more complex modifications. These features can be explained relatively easily by introducing extra LATER units, and enable them to be quantitatively parameterised; this potentially offers much more precise ways of quantifying the effects of such clinical conditions.
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