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Fabrication of PLGA/HAp and PLGA/PHB/HAp Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Krucińska I., Chrzanowska O., Boguń M., Kowalczuk M., Dobrzyński P.

Autex Research Journal

2014

Vol. 14, no. 2

95--110

The study presents the manufacturing of nanofibrous structures as osteoconductive, osteoinductive materials for osseous tissue regeneration. The fibrous structures were obtained by electrospinning of poly(l-lactide-coglicolide) (PLGA) with addition of hydroxyapatite (HAp) and of a blend of PLGA with polyhydroxybutyrate with HAp added. The polymers used in the experiment were synthesised by an innovative method with a zirconium catalyst. First, the optimal electrospinning process parameters were selected. For the characterisation of the obtained osseous tissue reconstruction materials, the physical, macroscopic, functional, mechanical and thermal properties as well as crystallinity index were studied. The study of the radiation sterilisation influence on average molar mass, thermal and mechanical properties was made in order to analyse the degradation effect.

A revised surgical concept of anterior cruciate ligament replacement in a rabbit model : preliminary investigations

Ficek K., Wieczorek J., Stodolak-Zych E., Kosenyuk Y.

Engineering of Biomaterials

2012

Vol. 15, no. 113

33--34

In this project the anterior cruciate ligament (ACL) replacement in a rabbit model was performed for the preclinical phase of investigations of a new form of biomaterial i.e. polymer beads (granules). This material, based on resorbable aliphatic polyester (polylactide - PLA) was used as a filler of the bone tunnels to enhance tendon-to-bone healing. The high specific surface area and well known biocompatibility of this material designated it as an osteoconductive agent in reconstructive ligament surgery. Additionally, a new surgical concept was proposed which retains the natural elasticity of the harvested tendon. This method ensures fixation of the grafted tendon within the bone tunnels in their entire length.