Wyniki wyszukiwania - BazTech

1

Czy nowe antybiotyki spełnią nasze oczekiwania

Kuś Anna

Laboratorium - Przegląd Ogólnopolski

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2022

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nr 3

33--37

PL

Poszukiwanie nowych antybiotyków i modyfikacja już istniejących trwa, mimo że wymaga to dużych inwestycji, czasu i pracy. W poszukiwaniu alternatyw dla antybiotyków można podążać kilkoma drogami. Można próbować modyfikować istniejące antybiotyki, na które wiele bakterii wykształciło oporność, lub zastąpić je zupełnie nowymi antybiotykami czy np. bakteriofagami/lizynami. Można działanie antybiotyków wzmocnić. np. stosując adiuwanty, inhibitory enzymów inaktywujących je lub koniugaty antybiotyków czy antybiotyki z innymi czynnikami przeciwbakteryjnymi. Nowe antybiotyki stanowią jedyną szansę na powstrzymanie rozwoju niebezpiecznych zakażeń bakteryjnych.

EN

The search for new antibiotics and modifications of existing ones continues despite the fact that it requires considerable investment, time and work. In the search for alternatives to antibiotics, several paths can be followed. One can try to modify existing antibiotics to which many bacteria have developed resistance or replace them with completely new antibiotics or, for example, bacteriophages/lysines. One can enhance the effect of antibiotics, e.g. by using adjuvants, enzyme inhibitors that inactivate them, or conjugates of antibiotics or antibiotics with other antimicrobial agents. New antibiotics are the only chance to stop the development of dangerous bacterial infections.

2

Experimental and theoretical study of the reinforced concrete flat slabs with the central support loss

Tur Viktar, Tur Andrei, Lizahub Aliaksandr

Inżynieria Bezpieczeństwa Obiektów Antropogenicznych

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2022

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Nr 4

12--41

EN

The paper experimentally and theoretically considers the issues of assessing the robustness and resistance to progressive collapse of a flat slab with a sudden removal of the central support. The results of testing two scale models of a fragment of a flat ceiling in the case of removal of the central support under static (specimen FS-1) and dynamic (specimen FS-2) loading are presented and analyzed. A theoretical approach to the quantitative assessment of robustness was tested, which is based on the provisions of the energy balance of a damaged structural system in an accidental design situation.

3

Modeling damaged precast structural system when its robustness check

Tur Viktar, Tur Andrei, Lizahub Aliaksandr

Inżynieria Bezpieczeństwa Obiektów Antropogenicznych

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2021

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Nr 3

63--81

EN

Within the framework of traditional approaches to checking for resistance of reinforced concrete buildings and structures to the progressive collapse development, membrane (chain) forces in a damaged structural system are calculated separately, without considering its non-linear bending behavior during the formation of the plastic hinges and without checking the possibility of achieving large deflections. The authors propose an approach to modelling a nonlinear quasi-static reaction of a damaged structural system in an accidental design situation. This approach considers non-linear bending and the resistance of reserved horizontal ties, considering their ultimate ductility. The authors verified the proposed approach based on the results of experimental studies by others researchers. An example of the application of the proposed approach in assessing the robustness of a structural system made of precast concrete with a sudden removal of the central column is considered. In accordance with the provisions of the energy approach, an analysis is made of the contribution of individual resistance mechanisms to the total quasi-static and dynamic resistance of the damaged structural system. We show that the proposed calculation model adequately describes the behavior of a damaged structural system in an accidental design situation, and therefore to carry out parametric studies and check the robustness of building structures.