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Content available remote Comparison of T-wave alternans detection methods
EN
T-wave alternans (TWA), which has recently been detected at the micro-volt level, is a non-invasive marker of the vulnerability to ventricular arrhythmia. The aim of this study was to compare the presently used TWA detection methods and to determine the ECG signal acquisition and processing conditions ensuring the TWA detection at its lowest possible level. The results of the evaluation and comparison of seven methods are presented. The ECG signal analysis was performed in the time and frequency domain. The differential and correlation methods were applied as the time domain methods. The complex demodulation method and methods based on the FFT and Karhunen-Loeve transform were tested as the frequency domain methods. The T-wave alternans markers were measured in 28 patients, and the results were compared. The usefulness of TWA detection methods has been demonstrated to dependant on the signal properties, such as the nonstationarity of TWA and the level of noise. Strong correlation between the magnitude of the T-wave alternans and ventricular repolarization time is described. A new, spectral methods is proposed.
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