Synthesis of 6-aminoindan-1-one and 7-amino-5,6-dimethoxyindan-1-one by nitration of corresponding indanones, followed by selective palladium catalyzed reduction under mild conditions has been described. Reactions of the amines with oxirane leading to N,N-bis-(beta-hydroxyethyl) derivatives were performed. The study of reductive amination of 6-nitroindan-1-one and 5,6-dimethoxy-7-nitroindan-1-one via azines to the corresponding amines as well as synthesis of N,N-bis-(beta-hydroxyethyl) derivatives of the amines was also described.
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