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Sodium alginate and pectin estimation in raft forming pharmaceuticals by high performance liquid chromatography method

Hanif Muhammad, Shah Shahid, Rasool Nasir, Abbas Ghulam, Saadullah Malik, Khan Sajid Mehmood, Ahmed Muhammad Masood, Abbas Nazar, Ashfaq Mehran, Iqbal Omeira

Acta Chromatographica

2021

Vol. 33, no. 2

127--133

The high performance liquid chromatographic (HPLC) method was developed for the combined estimation of sodium alginate and pectin in raft forming pharmaceuticals on C18 column ZORBAX ODS (1.5 cm × 4.6 mm, 5 μm) with UV detection at 378 nm. The assay condition comprised of phosphate buffer pH 7.4 and methanol 60:40% v/v at a flow rate of 1.25 mL/min. The separation of sodium alginate and pectin with good resolution and a retention time less than 8 min was attained. The method was linear over a range of 200–800 μg/mL of sodium alginate and pectin. The regression values obtained from linearity curve of sodium alginate and pectin were 0.9993 and 0.9991, respectively. The retention time of sodium alginate and pectin was 3.931 and 7.470 min, respectively. The percent recovery of sodium alginate and pectin ranged from 94.2–98.5% and 92.1–98.4% respectively. The limit of detection (LOD) and limit of quantification (LOQ) of sodium alginate were found to be 2.443 and 3.129 μg/mL and the LOD and LOQ of pectin were 3.126 and 3.785 μg/mL, respectively. The resolution of sodium alginate and pectin was found in the range of 1.03–1.89 and 1.10–1.91, respectively. This method has been successfully applied to analyze the concentrations of sodium alginate and pectin in raft forming drug delivery systems.

Influence of the Static Loading of a Raft Unconnected to a Pile on the Pile Displacements Tested in Field Conditions

Sedin Volodymyr, Bikus Kateryna, Kovba Vladyslav, Kononov Denys, Zahilskyi Vitalii

Civil and Environmental Engineering Reports

2019

Vol. 29, no. 2

22--30

We present the results of a static pile-raft interaction test in field conditions. The pile and the raft were unconnected. The static loading on the raft affected the displacements of the pile due to the skin friction. The displacements were also observed for another pile, placed at the 3-metre distance.