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Routine simultaneous production of no-carrier-added high purity 64Cu and 67Ga

Al Rayyes A. H., Ailouti Y.

Nukleonika

2011

Vol. 56, No. 4

259-262

A routine production method of no-carrier-added 64Cu was performed. A copper target support is electroplated by gold then an optimized thickness of enriched 68Zn layer is deposited. The 68Zn target was bombarded with a 23.5 MeV and 250 miA proton beam, generating the main nuclear reactions 68Zn(p,2n)67Ga and 68Zn(p,alfa n)64Cu. A semi-automated separation method using a chromatographic column system was developed for 64CuCl2 production. A 600 mCi batch of 64Cu is produced at the end of separation and purification chemistry. The radionuclidic purity of 64Cu was less than 98% as required by the United States and European Pharmacopoeias. Radiochemical purity and activity concentration is suitable for labeling different ligands to produce diagnostic and therapeutic radiopharmaceuticals.