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EN
The paper proposes an original, comprehensive, and methodically consistent graph theory-based approach to the description of the diagnosed process and the diagnosing system. The main baseline of the presented approach is in the dichotomous approach to diagnosing. It involves a separate description of both the process and the diagnostic system. This approach reflects the practice of designing implementable diagnostic systems. Thus, it can be seen as a proposal of a new, alternative, and, at the same time, flexible design procedure with great potential for applications. The primary motivation behind it was an attempt to circumvent the numerous limitations of well-known and well-established diagnosis approaches proposed by the communities working on fault detection and isolation (FDI) and artificial intelligence theories for diagnosis (DX). Accordingly, the paper identifies and provides an extensive discussion and a critical analysis of the existing limitations. Numerous examples and references to practical applications of the approach are indicated.
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Content available remote Reaction System Models for the Heat Shock Response
EN
Reaction systems are a formal framework for modeling processes driven by biochemical reactions. They are based on the mechanisms of facilitation and inhibition. A main assumption is that if a resource is available, then it is present in sufficient amounts and as such, several reactions using the same resource will not compete concurrently against each other; this makes reaction systems very different as a modeling framework than traditional frameworks such as ODEs or continuous time Markov chains. We demonstrate in this paper that reaction systems are rich enough to capture the essential characteristics of ODE-based models. We construct a reaction system model for the heat shock response in such a way that its qualitative behavior correlates well with the quantitative behavior of the corresponding ODE model. We construct our reaction system model based on a novel concept of dominance graph that captures the competition on resources in the ODE model. We conclude with a discussion on the expressivity of reaction systems as compared to that of ODE-based models.
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