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1 2016

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Synteza i aktywność biologiczna pochodnych pirolo[2,3-d]pirydazyny

Redzicka A., Tylińska B.

Wiadomości Chemiczne

2016

[Z] 70, 3-4

141--161

Pyrrolo[2,3-d]pyridazines are one of the four structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridazine ring. This review presents most of the literature data about synthetic pyrrolo[2,3-d]pyridazine derivatives and their biological activity. These 5,6-diazaindole analogues were first synthesized by Fischer et. al. in 1928. Compounds containing the pyrrolo[2,3-d] pyridazine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring on to pyridazine derivatives or annulation of pyridazine ring on to pyrrole derivatives. Pyrrolo[2,3-d]pyridazine derivatives have attracted considerable interest, owing to diverse biological activities. Most of them have been studied as antitumor and antiviral. Pyrrolo[2,3-d]pyridazines can also be used as acid pump antagonist.