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Związki metali jako potencjalne środki wspomagające promienioterapię

Kudak-Jaworowska Janina

Wiadomości Chemiczne

1999

[Z] 53, 5-6

349-377

This review describes some current approaches in using metal compounds to modulate the response of tumors and normal tissues to cell killing byionizing radiation. It is known that many tumors contain necrotic, oxygen-defficient areas which show diminished radiation sensitivity. Normal tissues contain mostly oxic cells; so antihypoxia therapies should be relatively tumor-specific. The biochemical role of oxygen is in fixing , or making permanent, the damage done to the critical DNA target. Radiation can damage DNA either by direct interaction or indirectly by ionizing created in nearby water molecules. The resulting DNA state depends on a competition between oxygen for damage fixation and reducing species, such as hydrated electron or thiol compounds (-SH), for chemical restitution. (...) Metal complexes would appear to represent ideal candidates for studies of their potential sensitizing properties, but only few such studies have been carried out. Metal complexes which exhibit greater radiosensitizing properties in hypoxia may be divided into three classes: (1) cisplatin and related Pt complexes; (2) metal (mainly Pt, Ru, Rh) complexes of nitroaromatic radiosensitizeres; (3) complexes of early transition metal series which may act by electron affinity or thiol depletion.(...)