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1 2012

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Degradation analysis of radiosensitizer control release system based on the NMR spectroscopy

Buszman A., Kasperczyk J., Jaworska J.

Engineering of Biomaterials

2012

Vol. 15, no. 113

16--18

The degradation process of multilayer radiosensitizer releasing systems was conducted and examined via the nuclear magnetic resonance spectroscopy. Copolymers of glycolide and lactide with different chain microstructure were used as biocompatible drug carriers. Metronidazole was used as radiosensitizer. The changes of copolymers chain microstructure were monitored during 16 weeks of hydrolytic degradation of material in artificial Cerebro-spinal Fluid Solution. This study shows distinct differences in the rate of copolymer degradation and changes of the degree of randomness, directly connected with the type of comonomers and the comonomeric molar ratio. During 16 weeks of hydrolytic degradation, copolymers with L-lactidyl units remain resistant to hydrolysis while materials with D,L-lactidyl units are completely degraded. Examined materials can be used as carriers of agents for different types of short-, mid- and long-term therapies based on control release systems.